Nrf2 Plays an Essential Role in Long-Term Brain Damage and Neuroprotection of Korean Red Ginseng in a Permanent Cerebral Ischemia Model

Antioxidants
Lei LiuSylvain Doré

Abstract

Cerebral ischemia is a devastating disease with a high incidence of death and disability; however, effective therapeutics remain limited. The transcriptional factor Nrf2 has been shown to play a pivotal role in the endogenous defense against brain oxidative stress and inflammation, and therefore represents a promising target for stroke intervention. However, the long-term effects of Nrf2 and the standardized Korean red ginseng (ginseng), a potent Nrf2 natural inducer, on permanent cerebral ischemic damage have not yet been reported. Wildtype (WT) and Nrf2-/- adult mice were pretreated with either vehicle or ginseng, and were subjected to permanent distal middle cerebral artery occlusion (pdMCAO). The infarct volume, the reactive astrocytes and microglia, and the water regulatory protein aquaporin 4 (AQP4) were examined at 28 days after stroke. When compared with the WT matched controls, the Nrf2 disruption significantly enlarged the infarct volume (40.4 ± 10.1%) and exacerbated the progression of reactive gliosis and AQP4 protein levels after pdMCAO. In contrast, ginseng significantly reduced the infarct volume and attenuated the reactive gliosis and AQP4 in the ischemic WT mice (47.3 ± 6.9%), but not in the Nrf2-/- mice (25.5 ...Continue Reading

References

Nov 4, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Andy Y ShihTimothy H Murphy
Jul 3, 2007·Free Radical Biology & Medicine·Jian WangSylvain Doré
Jun 6, 2009·Expert Reviews in Molecular Medicine·Marcelo R Vargas, Jeffrey A Johnson
May 6, 2010·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Zahoor A ShahSylvain Doré
Oct 1, 2010·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Yanxin Zhao, David A Rempe
Aug 20, 2011·Stroke; a Journal of Cerebral Circulation·Bing WangSylvain Doré
Jun 21, 2012·International Journal of Stroke : Official Journal of the International Stroke Society·Changhong XingMarc Hommel
Mar 14, 2013·Nature Reviews. Neuroscience·Marios C Papadopoulos, Alan S Verkman
Oct 10, 2013·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Michael V Sofroniew
Oct 19, 2013·Physiological Reviews·Erlend A Nagelhus, Ole P Ottersen
Nov 1, 2013·Journal of Neuroinflammation·Alexander V GlushakovSylvain Doré
Jan 28, 2014·Neuron·Joshua E Burda, Michael V Sofroniew
Feb 11, 2014·Methods in Molecular Biology·Kristian P Doyle, Marion S Buckwalter
Mar 22, 2014·Trends in Biochemical Sciences·John D Hayes, Albena T Dinkova-Kostova
Aug 26, 2014·Journal of Visualized Experiments : JoVE·Gemma LloveraArthur Liesz
Oct 13, 2014·Clinical Neurology and Neurosurgery·Wen-Wen WangGuo-Sheng Wang
Oct 29, 2014·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Elena González-BurgosM Pilar Gómez-Serranillos
Nov 9, 2014·Cold Spring Harbor Perspectives in Biology·Michael V Sofroniew
Feb 3, 2015·Frontiers in Cellular Neuroscience·Corinne BenakisJosef Anrather
Feb 6, 2015·Frontiers in Cellular Neuroscience·Vaibhav RastogiSylvain Doré
Apr 22, 2015·Nature Reviews. Neuroscience·Michael V Sofroniew
Apr 24, 2015·Frontiers in Cellular Neuroscience·Jasmine VellaMario Valentino
May 20, 2015·Neurobiology of Disease·Gourav Roy Choudhury, Shinghua Ding
Jul 15, 2015·Drug Design, Development and Therapy·Felix FluriChristoph Kleinschnitz
Aug 4, 2015·Frontiers in Aging Neuroscience·Wei-Yi OngEng-Ang Ling
Aug 14, 2015·Current Topics in Medicinal Chemistry·Yuyi WangJianping Liu
Oct 13, 2015·Progress in Neurobiology·Zhongwu Liu, Michael Chopp
Dec 17, 2015·Acta Neuropathologica·Milos PeknyAlexei Verkhratsky
Feb 7, 2016·Progress in Neurobiology·Yuanyuan MaGuo-Yuan Yang
Feb 13, 2016·Journal of Ginseng Research·Seyed Fazel NabaviSeyed Mohammad Nabavi
May 6, 2016·Stroke; a Journal of Cerebral Circulation·Carolee J WinsteinUNKNOWN American Heart Association Stroke Council, Council on Cardiovascular and Stroke Nursing, Council on Clinical Cardiology, and
Oct 21, 2016·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Egle Cekanaviciute, Marion S Buckwalter
Oct 4, 2016·Molecular Neurobiology·Rongrong ZhangXinyue Qin
Jan 7, 2017·Neurochemistry International·Neil R Sims, Wai Ping Yew
Jan 9, 2017·Acta Neuropathologica·Clemens J Sommer
Feb 9, 2017·Stroke; a Journal of Cerebral Circulation·Steven C CramerJoseph P Broderick
Mar 7, 2017·Acta Pharmacologica Sinica·Shou-Cai ZhaoFudong Liu
Mar 8, 2017·Stroke; a Journal of Cerebral Circulation·Clemens J Sommer, Wolf-Rüdiger Schäbitz
Apr 21, 2017·Neurology·Eduardo E Benarroch
Jul 29, 2017·Stroke; a Journal of Cerebral Circulation·Francesca BosettiWalter Koroshetz
Oct 14, 2017·International Journal of Molecular Sciences·Masato KanazawaTakayoshi Shimohata
Nov 18, 2017·Stroke; a Journal of Cerebral Circulation·Sean I SavitzMarc Fisher
Oct 20, 2018·Journal of Ginseng Research·Hyeon-Joong KimSeung-Yeol Nah

❮ Previous
Next ❯

Citations

Jul 16, 2020·International Journal of Molecular Sciences·Agnese GugliandoloEmanuela Mazzon
Apr 9, 2020·Frontiers in Cellular Neuroscience·Wei HouRanji Cui
Jul 27, 2021·Frontiers in Aging Neuroscience·Tao LvXiaohua Zhang
Jul 10, 2021·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Honglei RenJian Wang

❮ Previous
Next ❯

Software Mentioned

ImageScope
Prism
ScanScope CS

Related Concepts

Related Feeds

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.