Nrf2 protects mitochondrial decay by oxidative stress

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Joshua StromQin M Chen

Abstract

Sublethal levels of oxidative stress are commonly associated with various pathophysiological conditions. Cardiomyocytes have the highest content of mitochondria among all cell types, allowing the study of mitochondria in cells surviving oxidative stress and address whether nuclear factor-erythroid-derived 2-related factor 2 (Nrf2) can reverse these changes. Mitochondria normally exist in elaborated networks, which were replaced by predominately individual punctuate mitochondria 24 h after exposure to a nonlethal dose of H2O2. Electron microscopy revealed that cells surviving H2O2 show swelling of mitochondria with disorganized cristae and areas of condensation. Measurements of functional mitochondria showed a H2O2 dose-dependent decrease over a course of 5 d. At the protein and mRNA levels, cells surviving H2O2 treatment show a reduction of mitochondrial components, cytochrome c, and cytochrome b. Nrf2 overexpression prevented H2O2 from inducing mitochondria morphologic changes and reduction of cytochrome b/c. Although Nrf2 is known as a transcription factor regulating antioxidant and detoxification genes, Nrf2 overexpression did not significantly reduce the level of protein oxidation. Instead, Nrf2 was found to associate with ...Continue Reading

References

Sep 3, 1999·The Journal of Biological Chemistry·J AlamJ L Cook
Jan 6, 2000·Archives of Biochemistry and Biophysics·Q M ChenJ J Bahl
Aug 21, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·S P ElmoreJ J Lemasters
May 17, 2005·Experimental Cell Research·Gregory A DementRaymond Reeves
Sep 24, 2005·European Heart Journal·Joerg Herrmann
Sep 14, 2006·Annual Review of Pharmacology and Toxicology·Thomas W KenslerShyam Biswal
Nov 3, 2006·American Journal of Respiratory Cell and Molecular Biology·Dirk-Jan SlebosAugustine M K Choi
Nov 23, 2006·The Journal of Biological Chemistry·Kyle A Rasbach, Rick G Schnellmann
Mar 17, 2007·Annual Review of Biochemistry·Suzanne HoppinsJodi Nunnari
May 4, 2007·Archives of Biochemistry and Biophysics·Insil KimJohn J Lemasters
Jul 27, 2007·Molecular Pharmacology·Sally E Purdom-DickinsonQin M Chen
Apr 5, 2008·Experimental Cell Research·Shih-Ching Lo, Mark Hannink
Jul 12, 2008·Molecular Carcinogenesis·Wenge Li, Ah-Ng Kong
Nov 15, 2008·Journal of Molecular and Cellular Cardiology·Xiaoqing HeQiang Ma
Nov 18, 2008·Cell Death and Differentiation·M BakhanashviliG Rahav
Feb 3, 2009·The Journal of Biological Chemistry·Truyen NguyenCecil B Pickett
Mar 13, 2009·The Journal of Biological Chemistry·Ruben K DagdaCharleen T Chu
Mar 6, 2010·Circulation Research·Gwynngelle A BorilloMark A Sussman
Jul 16, 2010·Cardiovascular Research·Sang-Bing Ong, Derek J Hausenloy
Dec 31, 2011·Molecular & Cellular Proteomics : MCP·Jack ZhangQin M Chen
Jul 24, 2012·Trends in Endocrinology and Metabolism : TEM·Richard C ScarpullaDaniel P Kelly
Sep 1, 2012·Annual Review of Genetics·David C Chan
Sep 1, 2012·Science·Richard J Youle, Alexander M van der Bliek
Oct 16, 2012·Circulation Research·Dieter A Kubli, Åsa B Gustafsson

❮ Previous
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Citations

Jul 13, 2017·Vision Research·Renu A Kowluru
Jul 30, 2016·Journal of Applied Physiology·Matthew J CrillyDavid A Hood
Aug 2, 2018·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Sai-Chuen FuLeung-Kim Hung
Feb 28, 2019·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Govindhasamy Pushpavathi SelvakumarAsgar Zaheer
Dec 1, 2017·Physiological Genomics·Qin M Chen, Anthony J Maltagliati
Feb 27, 2019·Journal of Cellular Physiology·Mehrdad AghaeiVahid Khori
Feb 9, 2020·The International Journal of Neuropsychopharmacology·Gerwyn MorrisLisa Olive
Feb 28, 2020·Science Translational Medicine·Valerio AzzimatoMyriam Aouadi
May 14, 2020·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Sebastien GiraudThierry Hauet
May 18, 2019·Current Medicinal Chemistry·Robert E Smith
Sep 18, 2017·Journal of Biomedical Science·Tzu-Yu WengTsung-Ping Su
May 11, 2018·Scientific Reports·Abrar Ul Haq KhanMartin Villalba
May 13, 2018·Annals of the New York Academy of Sciences·Shaohua MaXiaoxin Luke Chen
Dec 10, 2019·Oxidative Medicine and Cellular Longevity·María L RodríguezÁngel Luis Ortega
Sep 6, 2019·Archives of Pharmacal Research·Hye-Youn Cho, Steven R Kleeberger
Jul 15, 2020·International Journal of Molecular Sciences·Cristiane F VillarrealMilena B P Soares
Oct 2, 2020·International Journal of Molecular Sciences·Kyung Hee LeeBae Hwan Lee
Feb 14, 2018·Expert Opinion on Therapeutic Targets·Renu A Kowluru, Manish Mishra
Nov 14, 2019·Cancers·Alina-Andreea ZimtaIoana Berindan-Neagoe
Jul 25, 2019·International Journal of Molecular Sciences·Farzane SivandzadeLuca Cucullo
May 30, 2020·Biomolecules·Jarmo Laihia, Kai Kaarniranta
Nov 27, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sarmistha SahaLuciano Saso
Aug 11, 2020·Neuroscience Letters·Abolfazl FattahMohsen Hemmati-Dinarvand
Sep 12, 2020·Journal of Ethnopharmacology·Rentsen BadamjavFang Li
Dec 15, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Xiang WangPeng Zhou
Apr 3, 2020·The Journal of Investigative Dermatology·Wei FangJinhua Xu
Apr 17, 2020·Progress in Retinal and Eye Research·Kai KaarnirantaDeborah Ferrington
Nov 7, 2020·International Journal of Biometeorology·Priya GaurPraveen Vats
May 29, 2019·European Journal of Pharmacology·Angela María Barrera-SandovalGloria Patricia Cardona-Gómez
Mar 3, 2018·Biochimica Et Biophysica Acta. Molecular Cell Research·Ilaria BellezzaRosario Donato

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