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Nrf2 Suppresses Oxidative Stress and Inflammation in App Knock-in Alzheimer's Disease Model Mice

Molecular and Cellular Biology

Jan 15, 2020

Akira UrunoMasayuki Yamamoto

Abstract

Nrf2 (NF-E2-related-factor 2) is a stress-responsive transcription factor that protects cells against oxidative stresses. To clarify whether Nrf2 prevents Alzheimer's disease (AD), AD model AppNL-G-F/NL-G-F knock-in (AppNLGF ) mice were studied in combination with genetic Nrf2 induction...read more

Mentioned in this Paper

Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Glutathione
Impaired Cognition
Elevation
8-oxo-7-hydrodeoxyguanosine
Wild Type Mouse
NFE2 gene
Biological Markers
Knock-in
CNS - Brain (Mmhcc)
4
1
Paper Details
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Nrf2 Suppresses Oxidative Stress and Inflammation in App Knock-in Alzheimer's Disease Model Mice

Molecular and Cellular Biology

Jan 15, 2020

Akira UrunoMasayuki Yamamoto

PMID: 31932477

DOI: 10.1128/mcb.00467-19

Abstract

Nrf2 (NF-E2-related-factor 2) is a stress-responsive transcription factor that protects cells against oxidative stresses. To clarify whether Nrf2 prevents Alzheimer's disease (AD), AD model AppNL-G-F/NL-G-F knock-in (AppNLGF ) mice were studied in combination with genetic Nrf2 induction...read more

Mentioned in this Paper

Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Glutathione
Impaired Cognition
Elevation
8-oxo-7-hydrodeoxyguanosine
Wild Type Mouse
NFE2 gene
Biological Markers
Knock-in
CNS - Brain (Mmhcc)
4
1

Similar Papers Found In These Feeds

Nrf2 Signaling in Inflammation

Nrf2 facilitates the recruitment of inflammatory cells, regulates expression of anti-inflammatory genes through the antioxidant response element, and plays a role in regulation of the inflammasome. Here is the latest research on Nrf2 signaling in inflammation.

Alzheimer's Disease: Genes&Microglia

Genes and microglia are associated with the risk of developing and the progression of conditions such as Alzheimer's Disease (AD). Here are the latest discoveries pertaining to this disease.

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