NS1 codon usage adaptation to humans in pandemic Zika virus

Memórias do Instituto Oswaldo Cruz
Caio César de Melo FreirePaolo M de A Zanotto

Abstract

Zika virus (ZIKV) was recognised as a zoonotic pathogen in Africa and southeastern Asia. Human infections were infrequently reported until 2007, when the first known epidemic occurred in Micronesia. After 2013, the Asian lineage of ZIKV spread along the Pacific Islands and Americas, causing severe outbreaks with millions of human infections. The recent human infections of ZIKV were also associated with severe complications, such as an increase in cases of Guillain-Barre syndrome and the emergence of congenital Zika syndrome. To better understand the recent and rapid expansion of ZIKV, as well as the presentation of novel complications, we compared the genetic differences between the African sylvatic lineage and the Asian epidemic lineage that caused the recent massive outbreaks. The epidemic lineages have significant codon adaptation in NS1 gene to translate these proteins in human and Aedes aegypti mosquito cells compared to the African zoonotic lineage. Accordingly, a Brazilian epidemic isolate (ZBR) produced more NS1 protein than the MR766 African lineage (ZAF) did, as indicated by proteomic data from infections of neuron progenitor cells-derived neurospheres. Although ZBR replicated more efficiently in these cells, the diff...Continue Reading

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Citations

Jun 8, 2018·Frontiers in Microbiology·Hong-Wai ThamMiaw-Fang Chew
Sep 27, 2019·Frontiers in Microbiology·Carolina Quintero-GilJulian Ruiz-Saenz

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Datasets Mentioned

BETA
KF383118
KU866423

Methods Mentioned

BETA
PCA

Software Mentioned

Andromeda
Emboss package
R
HyPhy
FUBAR
R Seqin { R
package Pvclust
Seqin R
Emboss
package ggbiplot

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