NS5ATP9 gene regulated by NF-kappaB signal pathway

Archives of Biochemistry and Biophysics
Kang LiJun Cheng

Abstract

NS5ATP9 was previously identified as p15 PAF [proliferating cell nuclear antigen (PCNA)-associated factor] to bind with PCNA. We earlier identified the promoter region of NS5ATP9 and found NS5ATP9 is a NS5A up-regulation gene. However little is known about how it is regulated. To investigate the gene regulation of NS5ATP9, we screened NS5ATP9 promoter binding proteins using phage display and verified by electrophoretic mobility shift assay (EMSA). We found that the nuclear protein rhNF-kappaB (p50) could bind to the NS5ATP9 promoter and the binding region contained within a 156 bp (nucleotides -5 to -161bp) immediately upstream of the transcription initiation site. Our results suggest that NF-kappaB could participate in the regulation of NS5ATP9 gene expression in carcinogenesis.

References

Aug 4, 2001·The American Journal of Pathology·F ChenX Shi
Sep 17, 2004·Genes & Development·Matthew S Hayden, Sankar Ghosh
Apr 28, 2005·Virchows Archiv : an International Journal of Pathology·Xavier DolcetXavier Matias-Guiu
Oct 27, 2005·Journal of Biochemistry and Molecular Biology·Shishir Shishodia, Bharat B Aggarwal
Nov 18, 2005·Experimental Cell Research·Fiona SimpsonCarol Wicking
Mar 23, 2006·Proceedings of the National Academy of Sciences of the United States of America·R EldorD Melloul
Dec 11, 2007·Cancer Letters·Lei ShiJun Cheng

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Citations

Mar 19, 2014·The International Journal of Biochemistry & Cell Biology·Chanlu XieQihan Dong
Oct 23, 2013·Laboratory Investigation; a Journal of Technical Methods and Pathology·Yao ChengChengxue Dang
Dec 12, 2017·Journal of Cellular Physiology·Hongping LuJun Cheng
May 12, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Lijuan LiuFan Zhu
Jan 19, 2018·Molecular Medicine Reports·Hangwei FuPing Chen
Apr 23, 2014·Journal of Viral Hepatitis·M QuanJ Cheng

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