PMID: 9437061Mar 28, 1998Paper

NSAID injury to the small intestine

Abdominal Imaging
A H ZalevR E Warren

Abstract

To identify the clinical and radiologic findings in patients with diaphragm-like strictures in the small bowel. We reviewed the histories, radiologic findings, and pathologic findings in two men and two women, all in their sixties, with a history of long-term nonsteroidal antiinflammatory drug (NSAID) or aspirin (ASA) usage and one or more radiologically demonstrated diaphragm-like strictures in the small bowel. Two patients had long histories of NSAID usage, and two of ASA usage. One NSAID user had a long segment of jejunal involvement, and the other three had short segments of duodenal involvement. The ASA users presented with symptoms of esophageal disease, the small bowel lesions were unexpected, and ASA usage was not initially elicited. In one NSAID user and one ASA user, broader strictures with humps rather than diaphragms were also seen producing a lifesaver-like or bagel-like configuration. Multiple diaphragm-like strictures can occur in NSAID injury and are pathognomonic except in the rare patient with ulcerative enteritis complicating celiac disease. Single or few diaphragm-like strictures can occur in NSAID injury and peptic ulceration. ASA should be considered an NSAID with regard to small-bowel toxicity. A careful ...Continue Reading

Citations

Jun 10, 2005·Annals of Diagnostic Pathology·Bihong ZhaoMahmoud Eltorky
Jan 5, 2002·Gastroenterology Clinics of North America·C W Houchen
Oct 12, 2011·World Journal of Gastroenterology : WJG·Ming-Liang WangFei Yuan
Jan 24, 2014·AJR. American Journal of Roentgenology·Kristina T FlicekC Daniel Johnson
May 14, 2011·Digestive Diseases and Sciences·Takayuki MatsumotoMitsuo Iida
Jun 1, 2010·Surgical Pathology Clinics·Ilyssa O GordonAmy E Noffsinger
Aug 16, 2003·British Journal of Clinical Pharmacology·Simon Smale, Ingvar Bjarnason
Aug 29, 2000·Inflammatory Bowel Diseases·L B Gerson, G Triadafilopoulos
Jul 26, 2006·Critical Reviews in Food Science and Nutrition·Katrien SwennenJan A Delcour

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