NSAIDs and breast cancer: a possible prevention and treatment strategy

International Journal of Clinical Practice
A Agrawal, I S Fentiman

Abstract

Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit cyclooxygenase (COX) and thereby reduce prostaglandin synthesis. Abnormally upregulated COX and prostaglandins are features of breast cancer so NSAIDs might have a role in treatment and prevention of the disease. To review the available epidemiological data on the relation between NSAIDs and risk of breast cancer together with interventional studies in established disease. Both case-control and cohort studies indicate a moderate reduction in risk of breast cancer among women taking NSAID particularly aspirin. There may be a reduction in oestrogen receptor positive tumours in aspirin users but results are heterogeneous. It is not possible to estimate the dose-response effect for duration of use. In patients with breast cancer, aspirin increased levels of serum nitric oxide (NO) and maspin both of which inhibit growth of breast cancer cells in vitro. Furthermore, a reduced breast cancer and all-cause mortality has been reported in those taking NSAIDs after diagnosis. The cyclooxygenase 2 (COX-2) inhibitor celecoxib showed promising preliminary efficacy and acceptability in combination with exemestane in advanced breast cancer although cardiotoxicity led to discontinuation of ...Continue Reading

References

Nov 18, 1989·BMJ : British Medical Journal·A Paganini-HillB E Henderson
Oct 1, 1980·Journal of the National Cancer Institute·G D Friedman, H K Ury
Mar 1, 1995·Preventive Medicine·L Rosenberg
Mar 1, 1995·Preventive Medicine·R E HarrisE L Wynder
Mar 1, 1994·Epidemiology·D M Schreinemachers, R B Everson
Mar 1, 1993·Postgraduate Medical Journal·M Odeh
Oct 1, 1995·Palliative Medicine·V Pace
Jul 17, 1996·Journal of the National Cancer Institute·K M EganG A Colditz
Mar 1, 1996·Epidemiology·R E HarrisW B Farrar
Dec 1, 1996·Gastroenterology Clinics of North America·R N DuBoisW E Smalley
Jan 29, 2000·Alimentary Pharmacology & Therapeutics·J M SeagerC J Hawkey
May 5, 2001·British Journal of Cancer·S A Khuder, A B Mutgi
Feb 21, 2002·Journal of the National Cancer Institute·Michael J ThunCarlo Patrono
Jun 22, 2002·Annals of Oncology : Official Journal of the European Society for Medical Oncology·G DaviesM Dowsett
Aug 8, 2002·Journal of the National Cancer Institute·Kristin E AndersonAaron R Folsom
Nov 29, 2002·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·C BosettiC La Vecchia
May 29, 2003·British Journal of Cancer·H T SørensenJ A Baron
Nov 19, 2003·The Journal of Steroid Biochemistry and Molecular Biology·Louis W C ChowMasakazu Toi
Jan 22, 2004·Chemistry : a European Journal·Andreas KrebsMichael W Göbel
May 27, 2004·JAMA : the Journal of the American Medical Association·Mary Beth TerryAlfred I Neugut
Jul 1, 2004·British Journal of Cancer·L A García Rodríguez, A González-Pérez
Jun 2, 2005·Journal of the National Cancer Institute·Sarah F MarshallRonald K Ross
May 3, 2006·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·K McCarthyP J Jenkins
Jul 11, 2006·Breast Cancer Research and Treatment·Cindy K BlairAaron R Folsom
Sep 1, 2006·The New England Journal of Medicine·Nadir ArberUNKNOWN PreSAP Trial Investigators
Oct 10, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P A CanneyJ Curto
Jan 25, 2007·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Michikazu OnoKojiro Shimozuma
Jan 25, 2007·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Rieko NishimuraShigemitsu Takashima
Apr 19, 2007·Journal of the National Cancer Institute·Eric J JacobsEugenia E Calle
Aug 4, 2007·Breast Cancer Research and Treatment·Ann ReadyEmily White

❮ Previous
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Citations

Nov 1, 2011·Breast Cancer Research and Treatment·Jennifer StoneJohn Hopper
Jan 1, 2010·Chemical Research in Toxicology·Irene Zagol-IkapitteOlivier Boutaud
Dec 2, 2008·Journal of Psychosocial Oncology·Suzanne C O'NeillMarc D Schwartz
Oct 9, 2008·Journal of the National Cancer Institute·Bahi TakkoucheMahyar Etminan
Jul 29, 2010·Journal of Clinical Biochemistry and Nutrition·Jun-Hee KimSung-Dae Cho
May 16, 2014·Current Breast Cancer Reports·Beate C Litzenburger, Powel H Brown
Jul 6, 2014·Biological & Pharmaceutical Bulletin·Kenta YagiToshiaki Sendo
Jan 12, 2016·Journal of Medicinal Chemistry·Daniel PlanoArun Kumar Sharma
Jul 23, 2015·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·M A Altinoz, N E Tunalı
Nov 26, 2009·Clinical Breast Cancer·Matias E ValsecchiWilliam Tester
Dec 4, 2009·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Amit B Shirode, Paul W Sylvester
Jul 28, 2009·The Breast : Official Journal of the European Society of Mastology·Tallal YounisPenny J Barnes
Nov 18, 2008·Journal of Controlled Release : Official Journal of the Controlled Release Society·Angel TanClive A Prestidge
Sep 9, 2008·Trends in Molecular Medicine·Hedi HariziNorbert Gualde
Feb 26, 2016·Breast Cancer Research and Treatment·Sanja B TurturroAbde M Abukhdeir
Jun 13, 2008·International Journal of Cancer. Journal International Du Cancer·Hang Xiao, Chung S Yang
Nov 22, 2012·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·V R KatkooriW E Grizzle
Aug 6, 2016·Cellular and Molecular Life Sciences : CMLS·Dequina A NicholasGerald V Denis
Mar 30, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ying HuJun Jiang
Dec 24, 2010·The Korean Journal of Internal Medicine·Soung Won JeongBoo Sung Kim
Apr 5, 2012·Nature Reviews. Clinical Oncology·Michael J ThunCarlo Patrono
Sep 8, 2017·Journal of the Royal Society, Interface·Dominik WodarzNatalia L Komarova
Mar 13, 2020·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Natalia L KomarovaDominik Wodarz
Jun 3, 2017·International Journal of Inflammation·Anthony M KyriakopoulosVasilleios Zoumpourlis
Jun 18, 2011·Archiv der Pharmazie·Wukun LiuRonald Gust
Jun 14, 2014·Oncology Reports·Nadia J Jacobo-HerreraAlejandro Zentella-Dehesa
Apr 7, 2017·Journal of Women's Health·Kathleen M McClainMarilie D Gammon
Mar 20, 2019·Clinical and Experimental Pharmacology & Physiology·Sarvenaz KashefiAbbas Mirshafiey
Nov 14, 2019·Medicinal Research Reviews·Jennifer R BakerAdam McCluskey

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