nSARS-Cov-2, pulmonary edema and thrombosis: possible molecular insights using miRNA-gene circuits in regulatory networks

ExRNA
P KhuranaB. Kumar

Abstract

Given the worldwide spread of the novel Severe Acute Respiratory Syndrome Coronavirus 2 (nSARS-CoV-2) infection pandemic situation, research to repurpose drugs, identify novel drug targets, vaccine candidates have created a new race to curb the disease. While the molecular signature of nSARS-CoV-2 is still under investigation, growing literature shows similarity among nSARS-CoV-2, pulmonary edema, and thromboembolic disorders due to common symptomatic features. A network medicine approach is used to to explore the molecular complexity of the disease and to uncover common molecular trajectories of edema and thrombosis with nSARS-CoV-2. A comprehensive nSARS-CoV-2 responsive miRNA: Transcription Factor (TF): gene co-regulatory network was built using host-responsive miRNAs and it's associated tripartite, Feed-Forward Loops (FFLs) regulatory circuits were identified. These regulatory circuits regulate signaling pathways like virus endocytosis, viral replication, inflammatory response, pulmonary vascularization, cell cycle control, virus spike protein stabilization, antigen presentation, etc. A unique miRNA-gene regulatory circuit containing a consortium of four hub FFL motifs is proposed to regulate the virus-endocytosis and antig...Continue Reading

References

May 11, 2000·Seminars in Thrombosis and Hemostasis·T MatsuoS Suzuki
Nov 28, 2001·British Journal of Haematology·R KerrC A Ludlam
Apr 23, 2002·Nature Genetics·Shai S Shen-OrrUri Alon
Jan 10, 2003·Nucleic Acids Research·V MatysE Wingender
Apr 16, 2003·The New England Journal of Medicine·Nelson LeeJoseph J Y Sung
Oct 8, 2003·Proceedings of the National Academy of Sciences of the United States of America·S Mangan, U Alon
Jan 27, 2004·Current Medical Research and Opinion·Edward Tobinick
Feb 11, 2004·Chest·Ulrike Bartram, Christian P Speer
Jan 1, 2005·Genomics, Proteomics & Bioinformatics·Yongwu HuHuanming Yang
Dec 31, 2005·Nucleic Acids Research·Sarah K Kummerfeld, Sarah A Teichmann
Mar 23, 2006·Annual Review of Immunology·Ming O LiRichard A Flavell
Jul 7, 2007·Molecular Cell·Andrew GrimsonDavid P Bartel
May 3, 2008·Proceedings of the National Academy of Sciences of the United States of America·Jidong ZhuJunying Yuan
Aug 12, 2008·Cell·Ming O Li, Richard A Flavell
Dec 3, 2008·The European Respiratory Journal·M InfanteG Ravasi
Mar 11, 2009·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Natalia J Martinez, Albertha J M Walhout
Mar 17, 2009·Genome Biology·Debra L FultonRob Sladek
Apr 20, 2010·BMC Bioinformatics·Sanghamitra Bandyopadhyay, Malay Bhattacharyya
Nov 12, 2010·Nucleic Acids Research·David CroftLincoln Stein
Apr 13, 2011·Molecular BioSystems·Debarka Sengupta, Sanghamitra Bandyopadhyay
Jul 23, 2011·Experimental Lung Research·Lili JiangXueshan Qiu
Feb 5, 2013·Briefings in Bioinformatics·Jakob Lewin RukovNoam Shomron
Mar 19, 2014·Blood·Silvio Antoniak, Nigel Mackman
Apr 8, 2014·Biochimica Et Biophysica Acta·Gabriel BretonesJavier León
Jul 6, 2014·Cold Spring Harbor Perspectives in Medicine·Steven B McMahon
Jul 16, 2014·Inflammation & Allergy Drug Targets·Ravinder Reddy GaddamMadhav Bhatia
Aug 12, 2014·Viruses·Ruth McBrideBurtram C Fielding
Feb 28, 2015·Methods in Molecular Biology·Anthony R Fehr, Stanley Perlman
Mar 5, 2015·Virus Research·Dong Yang, Julian L Leibowitz
Nov 4, 2015·MicroRNA·Perwez AlamNeeru Saini
Nov 19, 2015·Nucleic Acids Research·Robert LesurfUNKNOWN Open Regulatory Annotation Consortium
Aug 4, 2016·Mini Reviews in Medicinal Chemistry·Jinlian WeiQidong You

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Clinical Trials Mentioned

NCT04275414

Software Mentioned

igraph R - package
Reactome pathway analyser
house
Pharmaco
MultimiR R package
miR

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