NT-proBNP levels and their relationship with systemic ventricular impairment in adult patients with transposition of the great arteries long after Mustard or Senning procedure

Clinical Chemistry and Laboratory Medicine : CCLM
Karel KotaskaRichard Prusa

Abstract

The aim of the study was to investigate serum NT-proBNP levels in adult patients with transposition of the great arteries (d-TGA) corrected by atrial switch procedures (Mustard or Senning) operation and to assess the relationship with ventricular impairment and NYHA class. Serum NT-proBNP levels were measured in a group of 81 consecutive adult patients (59 males, mean age 27 years and 22 females, mean age 28 years) with transposition of the great arteries (TGA) after surgical correction in childhood, and in a control group of 25 healthy individuals (16 males, mean age 32 years, and 9 females, mean age 29 years). Age-matched correlation of NT-proBNP concentrations in TGA patients after Mustard or Senning correction was performed, but this correlation was considered not significant (p=0.08). Concentrations of NT-proBNP in patients with TGA were significantly elevated compared to the control group of healthy individuals (203 ng/L vs. 41 ng/L, p<0.0001). Patients after the Mustard repair had significantly higher NT-proBNP values than patients after the Senning operation (234 ng/L vs. 148 ng/L, p=0.0023). NT-proBNP correlated negatively with the systemic right ventricular ejection fraction with the greatest significance in patients ...Continue Reading

References

Aug 29, 2006·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Karel KotaskaRichard Prusa
Mar 10, 2010·The American Journal of Cardiology·Georgios GiannakoulasMichael A Gatzoulis
Apr 10, 2012·The Canadian Journal of Cardiology·Jana PopelováMiroslav Rubáček
Aug 7, 2013·Journal of the American College of Cardiology·Jannet A EindhovenJolien W Roos-Hesselink

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Citations

Sep 26, 2015·The American Journal of Cardiology·Jana Rubáčková PopelováJakub Tomek
Jan 29, 2020·Cardiovascular Ultrasound·Daniel SamaraiJoanna Hlebowicz

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