NT-proBNP levels, echocardiographic findings, and outcomes in breathless patients: results from the ProBNP Investigation of Dyspnoea in the Emergency Department (PRIDE) echocardiographic substudy

European Heart Journal
Annabel A ChenJames L Januzzi

Abstract

The objective of this study was to determine the integrative utility of measuring plasma NT-proBNP levels with echocardiography in the evaluation of dyspnoeic patients. Of 599 emergency department patients enrolled in a clinical study of NT-proBNP at a tertiary-care hospital, 134 (22%) had echocardiographic results available for analysis. Echocardiographic parameters correlating with NT-proBNP levels were determined using multivariable linear-regression analysis. Independent predictors of 1-year mortality were determined using Cox-proportional hazard analysis. Independent relationships were found between NT-proBNP levels and ejection fraction (P = 0.012), tissue Doppler early and late mitral annular diastolic velocities (P = 0.007 and 0.018), right ventricular (RV) hypokinesis (P = 0.006), and tricuspid regurgitation severity (P < 0.001) and velocity (P = 0.007). An NT-proBNP level <300 pg/mL had a negative predictive value of 91% for significant left ventricular systolic and diastolic dysfunction. Overall 1-year mortality was 20.1% and was independently predicted by NT-proBNP level [HR 8.65, 95% confidence interval (CI) 2.7-27.8, P = 0.0003], ejection fraction (HR 0.95, 95% CI 0.91-0.99, P = 0.009), RV dilation (HR 2.98, 95% C...Continue Reading

References

Feb 15, 1986·The American Journal of Cardiology·R B DevereuxN Reichek
Jul 1, 1994·Journal of the American College of Cardiology·G Y XieA N DeMaria
Jan 20, 1998·Lancet·T A McDonaghH J Dargie
Oct 6, 2001·The New England Journal of Medicine·J A de LemosE Braunwald
Dec 12, 2001·Journal of the American College of Cardiology·J KoglinW vonScheidt
Jul 19, 2002·The New England Journal of Medicine·Alan S MaiselUNKNOWN Breathing Not Properly Multinational Study Investigators
Jul 2, 2003·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·William A ZoghbiUNKNOWN American Society of Echocardiography
Oct 3, 2003·Journal of the American College of Cardiology·Teresa S M TsangJames B Seward
Feb 21, 2004·Journal of the American College of Cardiology·Damien LogeartAlain Cohen Solal
Mar 19, 2004·Journal of the American College of Cardiology·Paul A HeidenreichPaul G Shekelle
Sep 18, 2004·The American Journal of Cardiology·Michael WeberChristian Hamm
Nov 2, 2004·Heart Failure Reviews·Lok Bin Yap
Apr 6, 2005·Journal of the American College of Cardiology·Paul A GrayburnUNKNOWN BEST Trial Echocardiographic Substudy Investigators
Apr 12, 2005·The American Journal of Cardiology·James L JanuzziKent B Lewandrowski

❮ Previous
Next ❯

Citations

Jan 7, 2010·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Claus LuersBurkert Pieske
Apr 29, 2010·Current Heart Failure Reports·Ravi V Shah, James L Januzzi
Apr 6, 2013·Journal of Cardiovascular Translational Research·James L Januzzi
Oct 4, 2012·Cardiology in Review·Shweta R Motiwala, James L Januzzi
Mar 21, 2009·American Journal of Therapeutics·Sandy M GreenJames L Januzzi
Dec 7, 2013·Journal of Cardiovascular Translational Research·Shweta R MotiwalaJames L Januzzi
Nov 13, 2013·European Heart Journal·Richard TroughtonJames L Januzzi
Dec 1, 2007·Biomarkers in Medicine·Wayne L MillerAllan S Jaffe
Sep 18, 2013·The International Journal of Cardiovascular Imaging·Cristian MornoşDragoş Cozma
Nov 13, 2013·Arquivos brasileiros de cardiologia·Cristian MornosAdina Ionac
Jan 1, 2016·European Journal of Internal Medicine·Alberto PalazzuoliRanuccio Nuti
Nov 26, 2008·Heart Failure Clinics·Sean P Collins, Alan B Storrow
Jun 12, 2009·European Journal of Heart Failure·Keyur B ShahChristopher R deFilippi
Oct 5, 2010·Congestive Heart Failure·Catherine LawMaya Guglin
Aug 29, 2012·Congestive Heart Failure·James L JanuzziChristopher DeFilippi
Sep 8, 2015·Annals of Emergency Medicine·Susan R WilcoxRichard N Channick
May 6, 2015·Emergency Medicine Australasia : EMA·Anne-Maree KellyUNKNOWN AANZDEM Study Group
Jun 12, 2013·Journal of the American College of Cardiology·Clyde W YancyUNKNOWN American Heart Association Task Force on Practice Guidelines
Mar 19, 2013·Journal of the American College of Cardiology·James L Januzzi
Jun 1, 2014·European Journal of Preventive Cardiology·Ellen K HoogeveenErik J Giltay
Jul 19, 2016·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Maria Anastasia RicciGraziana Lupattelli
Apr 30, 2017·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Matt A RutzFrances M Russell
Nov 27, 2009·European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology·Leonidas V AthanasopoulosDennis V Cokkinos

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.