NTCP reduction for advanced head and neck cancer patients using proton therapy for complete or sequential boost treatment versus photon therapy

Acta Oncologica
Annika JakobiChristian Richter

Abstract

To determine by treatment plan comparison differences in toxicity risk reduction for patients with head and neck squamous cell carcinoma (HNSCC) from proton therapy either used for complete treatment or sequential boost treatment only. For 45 HNSCC patients, intensity-modulated photon (IMXT) and proton (IMPT) treatment plans were created including a dose escalation via simultaneous integrated boost with a one-step adaptation strategy after 25 fractions for sequential boost treatment. Dose accumulation was performed for pure IMXT treatment, pure IMPT treatment and for a mixed modality treatment with IMXT for the elective target followed by a sequential boost with IMPT. Treatment plan evaluation was based on modern normal tissue complication probability (NTCP) models for mucositis, xerostomia, aspiration, dysphagia, larynx edema and trismus. Individual NTCP differences between IMXT and IMPT (∆NTCPIMXT-IMPT) as well as between IMXT and the mixed modality treatment (∆NTCPIMXT-Mix) were calculated. Target coverage was similar in all three scenarios. NTCP values could be reduced in all patients using IMPT treatment. However, ∆NTCPIMXT-Mix values were a factor 2-10 smaller than ∆NTCPIMXT-IMPT. Assuming a threshold of ≥ 10% NTCP reduct...Continue Reading

References

Feb 1, 1997·International Journal of Radiation Oncology, Biology, Physics·A van't RietW van der Zee
Sep 15, 2009·International Journal of Radiation Oncology, Biology, Physics·Tiziana RancatiGiuseppe Sanguineti
Dec 17, 2009·International Journal of Radiation Oncology, Biology, Physics·Antonetta C HouwelingCornelis P J Raaijmakers
Aug 25, 2010·International Journal of Radiation Oncology, Biology, Physics·Tara A van de WaterJohannes A Langendijk
May 20, 2011·International Journal of Radiation Oncology, Biology, Physics·Avraham EisbruchRandall K Ten Haken
Sep 13, 2011·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Miranda E M C ChristianenJohannes A Langendijk
Jan 28, 2012·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Shreerang A BhideKevin J Harrington
Jul 10, 2012·Magnetic Resonance Imaging·Andriy FedorovRon Kikinis
Jun 14, 2013·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Johannes A LangendijkMarcel Verheij
Mar 29, 2014·Acta Oncologica·Ulrika LindblomPer Nilsson
Mar 1, 2015·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Birgit Sabine MüllerJan Jakob Wilkens

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Citations

Jul 11, 2016·Oral Oncology·Ester OrlandiPiero Fossati
Aug 28, 2016·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Takaaki YoshimuraShinichi Shimizu
Sep 19, 2017·Journal of Applied Clinical Medical Physics·Kristin StützerChristian Richter
Nov 18, 2017·Acta Oncologica·Cai GrauJens Overgaard
May 5, 2018·Physics in Medicine and Biology·Sang Hee AhnHee Chul Park
Mar 1, 2021·International Journal of Radiation Oncology, Biology, Physics·Pataje G PrasannaC Norman Coleman

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