NTRK fusion oncogenes in pediatric papillary thyroid carcinoma in northeast United States

Cancer
Manju L PrasadYuri E Nikiforov

Abstract

An increase in thyroid cancers, predominantly papillary thyroid carcinoma (PTC), has been recently reported in children. The histopathology of 28 consecutive PTCs from the northeast United States was reviewed. None of the patients (ages 6-18 years; 20 females, 8 males) had significant exposure to radiation. Nucleic acid from tumors was tested for genetic abnormalities (n = 27). Negative results were reevaluated by targeted next-generation sequencing. Seven of 27 PTCs (26%) had neurotrophic tyrosine kinase receptor (NTRK) fusion oncogenes (NTRK type 3/ets variant 6 [NTRK3/ETV6], n =5; NTRK3/unknown, n = 1; and NTRK type 1/translocated promoter region, nuclear basket protein [NTRK1/TPR], n = 1), including 5 tumors that measured >2 cm and 3 that diffusely involved the entire thyroid or lobe. All 7 tumors had lymphatic invasion, and 5 had vascular invasion. Six of 27 PTCs (22%) had ret proto-oncogene (RET) fusions (RET/PTC1, n = 5; RET/PTC3, n = 1); 2 tumors measured >2 cm and diffusely involved the thyroid, and 5 had lymphatic invasion, with vascular invasion in 2. Thirteen PTCs had the B-Raf proto-oncogene, serine/threonine kinase (BRAF) valine-to-glutamic acid mutation at position 600 (BRAF(V) (600E)) (13 of 27 tumors; 48%), 11 ...Continue Reading

References

Feb 1, 1995·Journal of Endocrinological Investigation·M A PierottiA Greco
May 1, 1996·The Journal of Clinical Endocrinology and Metabolism·I BongarzoneM A Pierotti
Feb 23, 1999·Recent Results in Cancer Research. Fortschritte Der Krebsforschung. Progrès Dans Les Recherches Sur Le Cancer·M A PierottiI Bongarzone
Apr 17, 2003·Journal of the National Cancer Institute·Yoram CohenDavid Sidransky
Sep 10, 2004·The Journal of Clinical Endocrinology and Metabolism·Atsushi KumagaiShunichi Yamashita
Oct 27, 2004·Laboratory Investigation; a Journal of Technical Methods and Pathology·Kerry J RhodenGiovanni Tallini
Apr 5, 2005·Cancer Research·Emanuela RoccatoAngela Greco
May 7, 2005·Thyroid : Official Journal of the American Thyroid Association·Karen PenkoGary Francis
Jun 22, 2005·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Eli RosenbaumWilliam H Westra
Feb 25, 2010·Annals of Surgical Oncology·Stephen B Edge, Carolyn C Compton
Sep 1, 2011·Nature Reviews. Endocrinology·Yuri E Nikiforov, Marina N Nikiforova
Feb 18, 2012·Histopathology·Alexander FinkelsteinManju L Prasad
Aug 28, 2013·The Journal of Clinical Endocrinology and Metabolism·Marina N NikiforovaYuri E Nikiforov
Oct 19, 2013·The Journal of Clinical Investigation·Julio C Ricarte-FilhoJames A Fagin
Dec 12, 2013·Cancer·Rebecca J Leeman-NeillYuri E Nikiforov
Oct 22, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Mingzhao XingVlasta Sýkorová
Nov 25, 2014·Cell·UNKNOWN Cancer Genome Atlas Research Network
May 2, 2015·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Yawei ZhangRobert Udelsman

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Citations

May 4, 2016·Current Opinion in Pediatrics·Andrew J Bauer, Gary L Francis
Nov 1, 2016·Thyroid : Official Journal of the American Thyroid Association·Paul WeinbergerAshok Sharma
Nov 23, 2016·Endocrine-related Cancer·Eric Y LianLois M Mulligan
Jan 18, 2017·Pediatric Blood & Cancer·Dean PavlickSiraj M Ali
Apr 26, 2017·Pediatric Blood & Cancer·Theodore W LaetschMichela Casanova
Mar 30, 2017·Thyroid : Official Journal of the American Thyroid Association·Keita IyamaShunichi Yamashita
May 31, 2017·Histopathology·Elizabeth Y WuJustine A Barletta
May 20, 2017·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Steven HardeeRaffaella A Morotti
Jul 8, 2017·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Jessica L DavisErin R Rudzinski
Oct 20, 2017·European Journal of Endocrinology·André Uchimura BastosJanete Maria Cerutti
Apr 24, 2018·The American Journal of Surgical Pathology·Cecilia LezcanoKlaus J Busam
Nov 8, 2017·Thyroid : Official Journal of the American Thyroid Association·Sogol Mostoufi-MoabAndrew J Bauer
Dec 29, 2017·Thyroid : Official Journal of the American Thyroid Association·Valentina D YakushinaAlexander V Lavrov
Sep 27, 2018·Cancer Biology & Therapy·Ling-Chuan GuoYi Zhang
Sep 19, 2018·Thyroid : Official Journal of the American Thyroid Association·Priya MahajanRajkumar Venkatramani
Oct 24, 2018·Expert Review of Anticancer Therapy·Theodore W Laetsch, Douglas S Hawkins
Jan 10, 2019·Annals of Oncology : Official Journal of the European Society for Medical Oncology·D S HongR C Doebele
Jan 23, 2019·European Journal of Endocrinology·K van der TuinH Morreau
Mar 30, 2019·Pediatric Blood & Cancer·Luiza SisdelliJanete Maria Cerutti
May 11, 2019·Journal of Clinical Pathology·Frédérique Penault-LlorcaAntonia R Sepulveda
Jun 1, 2019·Cancer Cytopathology·Esther Diana RossiLiron Pantanowitz
Jul 20, 2019·Endocrine Reviews·Maria E CabanillasCamilo Jimenez
Oct 18, 2019·Expert Review of Anticancer Therapy·Bridgette SchroaderKasia Shields
Apr 11, 2020·Pediatric Blood & Cancer·Pinki K PrasadRajkumar Venkatramani
Nov 17, 2017·The Journal of Pathology·Jialong LiangZhong Sheng Sun
Jun 5, 2020·Thyroid : Official Journal of the American Thyroid Association·Barbora PekovaBela Bendlova
Jun 20, 2020·The Journal of Clinical Endocrinology and Metabolism·Ali S AlzahraniMohamed Abouelhoda
Oct 2, 2020·Cancer Cytopathology·Roberto Ruiz-Cordero, Dianna L Ng
Jun 6, 2017·Cancer Cytopathology·Esther Diana RossiLuigi Maria Larocca
May 28, 2020·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Ying-Hsia ChuPeter M Sadow
Aug 2, 2020·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Ying-Hsia ChuPeter M Sadow
Sep 23, 2020·Diagnostic Pathology·Jeongwan KangSung-Hye Park
Jun 9, 2018·Journal of Hematology & Oncology·Yu Chen, Ping Chi
Apr 4, 2018·Cold Spring Harbor Molecular Case Studies·Rebecca RonsleyRebecca J Deyell
Dec 7, 2018·Thyroid : Official Journal of the American Thyroid Association·Carla ColomboLaura Fugazzola

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