Nuclear and chromatin reorganization during cell senescence and aging - a mini-review.

Gerontology
Dong-Myung ShinMariusz Z Ratajczak

Abstract

Genetic material in the nucleus governs mechanisms related to cell proliferation, differentiation, and function. Thus, senescence and aging are directly tied to the change of nuclear function and structure. The most important mechanisms that affect cell senescence are: (i) telomere shortening; (ii) environmental stress-mediated accumulation of DNA mutations, and (iii) the intrinsically encoded biological clock that dictates lifespan events of any particular cell type. Overall, these changes lead to modification of the expression of genes that are responsible for: (i) organization of the nuclear structure; (ii) integrity of transcriptionally inactive heterochromatin, and (iii) epigenetic modification of chromosomes due to DNA methylation and/or histone modifications. These aging-related nuclear alterations do not only affect somatic cells. More importantly, they affect stem cells, which are responsible for proper tissue rejuvenation. In this review, we focus on epigenetic changes in the chromatin structure and their impact on the biology and function of adult cells as they age. We will also address aging-related changes in a compartment of the most primitive pluripotent stem cells that were recently identified by our team and na...Continue Reading

References

Jun 3, 1983·Science·V L Wilson, P A Jones
Apr 12, 1996·Science·C E YuG D Schellenberg
May 29, 1998·Nature·J M ItierF Dautry
Feb 25, 2000·Mutation Research·J Vijg
Mar 17, 2001·Nature Reviews. Genetics·W Reik, J Walter
Aug 23, 2001·Proceedings of the National Academy of Sciences of the United States of America·M L HamiltonA Richardson
Jun 14, 2003·The EMBO Journal·Jaime Font de MoraEugenio Santos
Mar 1, 2005·Cell·Leonard Guarente, Frédéric Picard
Mar 5, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Stevens K RehenJerold Chun
Mar 31, 2005·Current Opinion in Genetics & Development·Raphael MargueronDanny Reinberg
Sep 17, 2005·Nature Reviews. Molecular Cell Biology·Haico van Attikum, Susan M Gasser
Jan 13, 2006·Trends in Biochemical Sciences·Robert J Klose, Adrian P Bird
Jun 2, 2006·Proceedings of the National Academy of Sciences of the United States of America·Dale K ShumakerRobert D Goldman
Jul 14, 2006·American Journal of Medical Genetics. Part a·Raoul C M Hennekam
May 25, 2007·Nature Reviews. Molecular Cell Biology·Armando van der Horst, Boudewijn M T Burgering
Jun 15, 2007·Trends in Genetics : TIG·Mario F Fraga, Manel Esteller
Jul 31, 2007·Cell·Manuel ColladoManuel Serrano
Aug 9, 2007·Nature Reviews. Molecular Cell Biology·Steven J Russell, C Ronald Kahn
Aug 19, 2007·Oncogene·A VaqueroD Reinberg
Aug 19, 2007·Nature Reviews. Molecular Cell Biology·Philipp Oberdoerffer, David A Sinclair
Aug 25, 2007·Nature Reviews. Molecular Cell Biology·Norman E Sharpless, Ronald A DePinho
Sep 19, 2007·Nature Chemical Biology·Maria A Blasco
Nov 7, 2008·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Ewa K Zuba-SurmaMariusz Z Ratajczak
Jan 3, 2009·Journal of the American College of Cardiology·Wojciech WojakowskiMariusz Z Ratajczak
Feb 28, 2009·Stroke; a Journal of Cerebral Circulation·Edyta PaczkowskaBoguslaw Machalinski
Apr 4, 2009·Science·Olaf BergmannJonas Frisén

❮ Previous
Next ❯

Citations

Jun 14, 2013·Molecular Biology of the Cell·Flávia Gerelli GhiraldiniMaria Luiza Silveira Mello
Mar 13, 2013·Regenerative Medicine·Ursula StochajInés Colmegna
Mar 21, 2012·Biochimica Et Biophysica Acta·Christophe E RedonWilliam M Bonner
Dec 29, 2011·Molecular Biology International·Ryuji OkazakiToshiyuki Norimura
Oct 30, 2013·Journal of Cellular Biochemistry·Henrique F RodriguesAlberto S Moraes
Aug 14, 2013·Clinical Endocrinology·Anna AulinasSusan M Webb
Jan 1, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Jun LiuYa-Ping Wang
Aug 2, 2017·Antioxidants & Redox Signaling·Rosa VonoPaolo Madeddu
Aug 19, 2014·Asian Pacific Journal of Tropical Medicine·Hong-Xue WuWei-Xing Wang
Apr 4, 2021·International Journal of Molecular Sciences·Silvia Ferrari, Maurizio Pesce

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Cancer Epigenetics and Senescence (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may be involved in regulating senescence in cancer cells. This feed captures the latest research on cancer epigenetics and senescence.

Related Papers

Differentiation; Research in Biological Diversity
Mariusz Z RatajczakDong-Myung Shin
Birth Defects Research. Part C, Embryo Today : Reviews
Junling Zhang, Zhenyu Ju
Antioxidants & Redox Signaling
Ursula Muñoz-Najar, John M Sedivy
© 2021 Meta ULC. All rights reserved