Nuclear and Optical Bimodal Imaging Probes Using Sequential Assembly: A Perspective

Cancer Biotherapy & Radiopharmaceuticals
Shin Hye Ahn, Eszter Boros

Abstract

New, targeted imaging tracers enable improved diagnosis, staging, and planning of treatment of disease and represent an important step toward personalized medicine applications. The combination of radioisotopes for nuclear imaging with fluorophores for fluorescence imaging provides the possibility to noninvasively assess disease burden in a patient using positron emission tomography/single-photon emission computed tomography, followed by fluorescence imaging-assisted surgical intervention in close succession. Probes enabling imaging with both modalities pose a design, synthesis, and pharmacokinetics challenge. In this study, the authors strive to summarize recent efforts toward optimized, discrete, bimodal probes as well as a perspective on future directions of this burgeoning subfield of targeted imaging probe development.

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Citations

Nov 13, 2019·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Fijs W B van LeeuwenTessa Buckle
Apr 4, 2020·Inorganic Chemistry·Neha ChoudharyChris Orvig
Aug 29, 2019·ACS Omega·Albertus W HensbergenFijs W B van Leeuwen

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Methods Mentioned

BETA
imaging techniques
xenografts
fluorescence imaging
fluorescence
xenograft

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