Nuclear BAP1 loss is common in intrahepatic cholangiocarcinoma and a subtype of hepatocellular carcinoma but rare in pancreatic ductal adenocarcinoma

Cancer Genetics
Asmaa MosbehMohamed H Abdel Rahman

Abstract

Deletion in the 3p21 region, the chromosomal location of BAP1, has been reported in a subset of hepatocellular carcinoma (HCC), biliary and pancreatic cancers. This suggests that BAP1 could play a role in the pathogenesis of these tumors. We assessed the frequency of BAP1 loss by immunohistochemistry in 103 hepatic, biliary and pancreatic cancers. We also assessed chromosomal alterations in the BAP1 region in the same tumors by genotyping. We identified high frequency 4/8 (50%) of BAP1 loss in intrahepatic cholangicarcinoma (ICC). However the frequency was lower in HCC 9/51 (17.6%), pancreatic 1/42(2.4%) and extrahepatic biliary cancers (0/2). Loss of heterozygosity of at least one marker from the 3p21 region was observed in 75% of ICC, 52.9% of HCC and 45.2% of pancreatic cancers. Expression of hepatocytic (HepPar1) and bile duct (cytokeratin 7) markers were common (7/9, 77.8%) in the HCC tumors with loss or decrease of BAP1 compared with those with preserved BAP1 (18/42, 42.9%), (Fisher exact p = 0.0751). Our results confirm the high frequency of BAP1 alterations in ICC and low frequency in pancreatic cancers. It also suggests that BAP1 is commonly altered in a subtype of HCC with both hepatocytic and biliary differentiation....Continue Reading

References

Jun 16, 2001·Cancer Genetics and Cytogenetics·R I SkotheimR A Lothe
Oct 5, 2001·Trends in Genetics : TIG·P DevileeC J Cornelisse
Apr 2, 2004·The American Journal of Gastroenterology·Kelly BurakKeith D Lindor
Jul 13, 2004·Cancer Science·Satoshi YamamotoTakashi Tanaka
Feb 11, 2005·International Journal of Cancer. Journal International Du Cancer·Iris TischoffAndrea Tannapfel
Jul 12, 2007·PLoS Medicine·Banchob SripaPaul J Brindley
Nov 6, 2010·Science·J William HarbourAnne M Bowcock
Aug 30, 2011·Nature Genetics·Joseph R TestaMichele Carbone
Aug 30, 2011·Nature Genetics·Thomas WiesnerMichael R Speicher
Sep 24, 2011·Journal of Medical Genetics·Mohamed H Abdel-RahmanFrederick H Davidorf
Nov 1, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Solange LandrevilleJ William Harbour
Dec 6, 2011·Epigenetics : Official Journal of the DNA Methylation Society·Erika da Costa PrandoCláudia Aparecida Rainho
Jun 12, 2012·Nature Genetics·Samuel Peña-LlopisJames Brugarolas
Sep 22, 2012·Science·Anne E White, J Wade Harper
May 21, 2013·American Journal of Human Genetics·Tatiana PopovaMarc-Henri Stern
Mar 19, 2014·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Anna E KoopmansAnnelies de Klein
May 6, 2015·Pathology·Mahtab FarzinAnthony J Gill
Jul 21, 2015·Experimental and Molecular Pathology·Juan PutraArief A Suriawinata
Jan 9, 2016·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Jan 15, 2016·Medicine·Juliana AndriciAnthony J Gill
Jun 9, 2016·Nature Medicine·Marie SchoumacherRaphaël Margueron

❮ Previous
Next ❯

Citations

Jun 5, 2019·Future Oncology·Vincenzo Di NunnoFrancesco Massari
Jun 14, 2020·Japanese Journal of Clinical Oncology·Guoping JiangShusen Zheng
Mar 19, 2019·Liver International : Official Journal of the International Association for the Study of the Liver·Timothy KendallGuido Carpino
Sep 19, 2020·Oral Diseases·Lucas Alves da Mota SantanaSílvia Ferreira de Sousa
Jan 20, 2021·Cell Death and Differentiation·Louis MasclefEl Bachir Affar

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adrenocortical Carcinoma

Hepatocellular carcinoma is the most common type of primary liver cancer and frequently occurs in individuals with chronic liver diseases like cirrhosis. Here is the latest research.

Carcinoma, Ductal

Ductal carcinoma is a malignant neoplasm involving the ductal systems of any of a number of organs, such as the mammary glands, pancreas, prostate or lacrimal gland. Discover the latest research on ductal carcinoma here.

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.