Nuclear BCL-10 expression is common in lymphoplasmacytic lymphoma/Waldenström macroglobulinemia and does not correlate with p65 NF-kappaB activation

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
Mihai MerzianuCarlos E Bueso-Ramos

Abstract

B-cell lymphoma 10 (BCL-10) is expressed in the cytoplasm of normal germinal center and marginal zone B-cells and is involved in lymphocyte development and activation. Aberrant nuclear expression of BCL-10 occurs in a subset of extranodal marginal zone B-cell lymphomas (MALT lymphomas), primarily those with the t(1;14)(p22;q32) or t(11;18)(q21;q21). Little is known about BCL-10 expression in lymphoplasmacytic lymphoma/Waldenström macroglobulinemia (LPL/WM). We assessed for BCL-10 in 51 bone marrow (BM) specimens involved by LPL/WM using immunohistochemical methods. All patients had monoclonal IgM in serum. Extent of BM involvement was assessed using PAX-5/BSAP and CD20 immunostains and the pattern and percentage of B-cells positive for BCL-10 was determined. The p65 subunit of nuclear factor-kappa B (NF-kappaB), a molecule downstream of BCL-10, was also assessed immunohistochemically. Nuclear BCL-10 staining was present in 28/51 (55%) specimens. BCL-10 expression correlated with greater extent of BM involvement (P=0.001), but did not correlate with serum IgM paraprotein levels, type of immunoglobulin light chain, or clinical variables. Nuclear expression of the p65 subunit of NF-kappaB was detected in 17/50 (34%) specimens, sug...Continue Reading

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Citations

Aug 19, 2006·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Sameer S TalwalkarL Jeffrey Medeiros
Mar 13, 2008·Blood·Xavier LeleuIrene M Ghobrial
Aug 22, 2007·American Journal of Clinical Pathology·Mar GarciaL Jeffrey Medeiros
Feb 18, 2009·British Journal of Haematology·Xavier LeleuSteven P Treon
Mar 21, 2009·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Margaret K GatumuKathrine Skarstein
Jun 25, 2010·Advances in Anatomic Pathology·Penelope A McKelvie
Jan 31, 2007·International Journal of Hematology·Miho KimuraHiroshi Shiku

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