Nuclear beta-catenin in mesenchymal tumors

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
Tony L NgTorsten O Nielsen

Abstract

Beta-catenin is a crucial part of the Wnt and E-cadherin signalling pathways, which are involved in tumorigenesis. Dysregulation of these pathways allow beta-catenin to accumulate and translocate to the nucleus, where it may activate oncogenes. Such nuclear accumulation can be detected by immunohistochemistry, which may be useful in diagnosis. Although the role of beta-catenin has been established in various types of carcinomas, relatively little is known about its status in mesenchymal tumors. A number of studies suggest that beta-catenin dysregulation is important in desmoid-type fibromatosis, as well as in synovial sarcoma. We wished to determine whether nuclear beta-catenin expression is specific to and sensitive for particular bone and soft-tissue tumors, including sporadic desmoid-type fibromatosis. We studied the nuclear expression of beta-catenin using tissue microarrays in a comprehensive range of bone and soft-tissue tumor types. A total of 549 cases were included in our panel. Nuclear immunohistochemical staining was determined to be either high level (>25% of cells), low level (0-25%) or none. High-level nuclear beta-catenin staining was seen in a very limited subset of tumor types, including desmoid-type fibromatos...Continue Reading

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Citations

Apr 1, 2008·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Chan-Kwon JungKyo-Young Lee
Nov 10, 2009·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Shuichi KuriharaMasazumi Tsuneyoshi
Apr 14, 2009·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Kemal KosemehmetogluAndrew L Folpe
May 2, 2009·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Sonja E SteigenTorsten O Nielsen
Aug 10, 2010·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Magali Lacroix-TrikiJorge S Reis-Filho
Nov 1, 2011·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Marina Pacheco, Torsten O Nielsen
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Jul 7, 2012·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Sophie Le GuellecJean-Michel Coindre
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