PMID: 590175Jan 1, 1977

Nuclear bodies of lymphocytes in the lymph nodes of guinea pigs treated with phytohemagglutinin in vivo

Eksperimentalna meditsina i morfologiia
N VasilevI Mikhaĭlov


Nuclear bodies (NB) were studied in guinea pigs regional lymph node cells after a single subcutaneous application of Phytohaemagglutinin Difco (PHA). A distinct reaction of the lymph node cells was established on the 3rd, 6th and 9th days consisting of increased number of lymphoblasts and large basophilic cells (LBC). Ultrastructural descriptive and morphometric methods were used. Authors revealed nuclear bodies to be present mostly in activated lymph node cells (lymphoblasts and LBC). Predominance of NB having RNP particles (complex type NB) was found. Simple NB (without RNP particles) had been seen rarely in small (resting lymphocytes. It was established NB to be larger, but leis im member. It is discussed on the participation of NB (Complex type) in the nuclear part of the protein synthesis.

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