PMID: 15223793Jun 30, 2004Paper

Nuclear cataract shows significant familial aggregation in an older population after adjustment for possible shared environmental factors

Investigative Ophthalmology & Visual Science
Nathan G CongdonSheila K West

Abstract

To quantify the association between siblings in age-related nuclear cataract, after adjusting for known environmental and personal risk factors. All participants (probands) in the Salisbury Eye Evaluation (SEE) project and their locally resident siblings underwent digital slit lamp photography and were administered a questionnaire to assess risk factors for cataract including: age, gender, lifetime sun exposure, smoking and diabetes history, and use of alcohol and medications such as estrogens and steroids. In addition, blood pressure, body mass index, and serum antioxidants were measured in all participants. Lens photographs were graded by trained observers masked to the subjects' identity, using the Wilmer Cataract Grading System. The odds ratio for siblings for affectedness with nuclear cataract and the sibling correlation of nuclear cataract grade, after adjusting for covariates, were estimated with generalized estimating equations. Among 307 probands (mean age, 77.6 +/- 4.5 years) and 434 full siblings (mean age, 72.4 +/- 7.4 years), the average sibship size was 2.7 per family. After adjustment for covariates, the probability of development of nuclear cataract was significantly increased (odds ratio [OR] = 2.07, 95% confid...Continue Reading

References

Jan 1, 1991·Genetic Epidemiology·K Y Liang, T H Beaty
Jan 1, 1995·Survey of Ophthalmology·S K West, C T Valmadrid
Dec 1, 1993·American Journal of Medical Genetics·I M HeibaR Klein
Feb 1, 1993·Current Eye Research·S K WestH Taylor
Dec 16, 1998·American Journal of Epidemiology·S K WestG S Rubin
Jan 22, 2000·Nippon Ganka Gakkai zasshi·T Amemiya
Jun 15, 2000·The New England Journal of Medicine·C J HammondC E Gilbert

❮ Previous
Next ❯

Citations

Aug 23, 2007·International Ophthalmology·Margaret A ChangAlfred Sommer
May 3, 2005·Experimental Eye Research·Roger J W Truscott
Nov 24, 2005·Eye·L Robman, H Taylor
Nov 19, 2004·The British Journal of Ophthalmology·A LewisS K West
Dec 19, 2012·Human Genomics·Konstantinos Sousounis, Panagiotis A Tsonis
Sep 21, 2010·Survey of Ophthalmology·Paul G SanfilippoDavid A Mackey
Aug 31, 2006·Veterinary Ophthalmology·David L Williams
May 5, 2006·Clinical & Experimental Ophthalmology·David A Mackey
Dec 15, 2011·Free Radical Research·Shipra MehraPramod Kumar Sehgal
Nov 29, 2017·Ophthalmic Epidemiology·Stephanie J LoomisPriya Duggal
Apr 13, 2007·Journal of Cellular Biochemistry·M BagchiH Maisel

❮ Previous
Next ❯

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
Sudha K IyengarRobert C Elston
The British Journal of Ophthalmology
A ChatterjeeS Thyle
© 2022 Meta ULC. All rights reserved