Nuclear coded mitochondrial protein prohibitin is an iron regulated iron binding protein

Mitochondrion
Sudharsana R Ande, Suresh Mishra

Abstract

Mitochondria are central to iron homeostasis. However, various proteins involved in iron metabolism inside the mitochondria are still to be identified. Herein we report that nuclear coded mitochondrial protein prohibitin binds to iron and involved in intracellular iron homeostasis. Like other iron regulated proteins, prohibitin mRNA contains functional iron-response element and is regulated by intracellular iron levels. Tyrosine residues involved in iron binding attribute of prohibitin are identified using site-directed mutagenesis. These data together suggest that prohibitin functions as an intracellular iron binding protein and plays a role in intracellular iron homeostasis.

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Citations

Nov 30, 2011·International Journal of Obesity : Journal of the International Association for the Study of Obesity·S R AndeS Mishra
Jan 19, 2013·Journal of Receptor and Signal Transduction Research·Tian-Biao Zhou, Yuan-Han Qin
Dec 22, 2017·Signal Transduction and Targeted Therapy·Sudharsana Rao AndeSuresh Mishra
Jan 14, 2018·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Gregory J ConnellChristian X Haastruthers
Apr 9, 2021·PLoS Neglected Tropical Diseases·Ana K Ibarrola-VannucciAntonio Osuna

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