Nuclear disconnection within the amygdala reveals a direct pathway to fear.

Learning & Memory
Stephanie A Jimenez, Stephen Maren

Abstract

It is widely believed that a descending serial circuit consisting of neural projections from the basolateral complex (BLA) to the central nucleus (CEA) of the amygdala mediates fear expression. Here we directly test this hypothesis and show that disconnecting the BLA and CEA with asymmetric neurotoxic lesions after Pavlovian fear conditioning in rats completely abolishes the expression of conditional freezing. These results demonstrate that neural projections from the BLA to CEA are essential for the expression of learned fear responses.

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Citations

May 7, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Giuliana CaroniaElizabeth A Grove
Sep 18, 2015·Frontiers in Systems Neuroscience·David N Silverstein, Martin Ingvar
Jan 10, 2013·Neurobiology of Learning and Memory·Cristina S FonsecaGrace S Pereira
Jun 22, 2011·Neurobiology of Learning and Memory·Carl W Stevenson
May 23, 2014·Frontiers in Behavioral Neuroscience·Vincent D CampeseChristopher K Cain
Apr 23, 2016·Neuron·Stephen Maren
Apr 29, 2018·Brain Structure & Function·C J Reppucci, G D Petrovich
Nov 19, 2015·Frontiers in Behavioral Neuroscience·Vincent D CampeseJoseph E LeDoux
Jul 19, 2019·Neuron·Drew B HeadleyDenis Paré
Sep 25, 2020·Physiological Reviews·Mark E BoutonGavan P McNally
May 23, 2012·Learning & Memory·Charlotte R Flavell, Jonathan L C Lee
Oct 18, 2013·Learning & Memory·Darrell HauflerDenis Pare

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