Nuclear dots: actors on many stages

Immunobiology
T SternsdorfH Will

Abstract

Nuclear dots (NDs), alternatively designated nuclear bodies (NBs), PML oncogenic domains (PODs), nuclear domain 10 (ND10) or Kr-bodies, became a major topic for researchers in many fields only recently. Originally described as an autoantigenic target in patients with primary biliary cirrhosis, they are now also known to play a role in development of acute promyelocytic leukemia (APL) and possibly other forms of neoplasia. Size, number and composition of NDs are regulated throughout the cell cycle. Infection with herpes simplex virus, adenovirus, cytomegalovirus, Epstein-Barr-virus, influenza virus and human T cell lymphotropic virus type I (HTLV I) strongly modifies ND structure through viral regulatory proteins. Due to this finding and because at least three of the cellular ND proteins are highly interferon-inducible, a function of NDs in early viral infection or in antiviral response has been postulated. Functional data are currently available only for two of the ND-associated proteins. The Sp100 protein seems to have transcriptional transactivating property, whereas the promyelocytic leukemia protein (PML) was reported to suppress growth and transformation. Here, we give a brief overview of the data currently available on ND...Continue Reading

References

Oct 1, 1992·Experimental Cell Research·K Brasch, R L Ochs
Feb 8, 1991·Cell·P S FreemontJ Trowsdale
Mar 1, 1991·The Journal of Cell Biology·C A Ascoli, G G Maul
May 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·T BoehmT H Rabbitts
Jan 1, 1990·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·U Scheer, R Benavente
Aug 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·N P AnagnouA W Nienhuis
Oct 1, 1995·The Journal of Cell Biology·T CarvalhoA Dejean
Nov 1, 1995·The Journal of General Virology·C KellyG W Wilkinson
Mar 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·R LoveringP S Freemont
Jun 1, 1995·The Journal of Experimental Medicine·J H LiuK S Chang
Apr 1, 1995·Genome Génome / Conseil National De Recherches Canada·D WeichenhanW Traut
Feb 28, 1995·Proceedings of the National Academy of Sciences of the United States of America·K Xie, M Snyder
Dec 1, 1993·Mammalian Genome : Official Journal of the International Mammalian Genome Society·S AgulnikH Winking
Oct 1, 1994·Molecular and Cellular Biology·Z M MuK S Chang
Jul 1, 1993·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·R M ZirbelP Lichter
Mar 1, 1994·Trends in Genetics : TIG·R GrosschedlJ Pagel
Oct 1, 1993·Molecular and Cellular Biology·K XieM Snyder
Jan 15, 1993·European Journal of Biochemistry·B WasylykA Giovane
May 25, 1993·Nucleic Acids Research·V LaudetH Clevers
Jan 5, 1996·The Journal of Biological Chemistry·X F LeK S Chang
Nov 15, 1996·The Journal of Biological Chemistry·D B BlochK D Bloch

❮ Previous
Next ❯

Citations

Aug 5, 2000·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·R D Everett
Dec 11, 1999·Cell Biochemistry and Biophysics·C T BaumannG L Hager
Sep 9, 2000·Current Opinion in Cell Biology·H Li, J D Chen
Jul 17, 1999·Trends in Cell Biology·A G Matera
Aug 4, 1999·Trends in Biochemical Sciences·R D Everett
Dec 20, 2002·Journal of Structural Biology·Almut KiesslichPeter Hemmerich
May 23, 2001·The Biochemical Journal·M Dundr, T Misteli
Jun 20, 2012·The Journal of Biological Chemistry·Sona HubackovaZdenek Hodny
Oct 14, 2000·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·J L TaylorK W Wilcox
Jan 13, 2000·Immunological Reviews·J YewdellJ R Bennink
Feb 13, 2009·Journal of Virology·Christos A Kyratsous, Saul J Silverstein
Mar 23, 2002·Molecular and Cellular Biology·Christine WasylykBohdan Wasylyk
Nov 5, 1999·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·C Kretz-Remy, R M Tanguay
Jul 6, 2014·PloS One·Mireia MoraEduardo Fernández-Rebollo
Aug 29, 2001·Human Mutation·M HeinoK Krohn
May 23, 2003·Cold Spring Harbor Symposia on Quantitative Biology·L WuI D Hickson
Jul 14, 1999·The Journal of Cell Biology·L C AntónJ W Yewdell
Mar 9, 2007·Biochimie·Roger D Everett, Mounira K Chelbi-Alix
Nov 22, 2001·Experimental Cell Research·A DrouinE M Cramer
Jul 31, 1998·American Journal of Human Genetics·M HodgesP S Freemont
Sep 2, 2003·The Journal of Pathology·Chong Jai KimEun-Sil Yu
Apr 27, 2005·The Journal of Gene Medicine·Delphine CuchetAlberto L Epstein
Nov 26, 2010·Clinical and Experimental Immunology·L M StintonM J Fritzler
Sep 18, 2001·Methods : a Companion to Methods in Enzymology·R N DayF Schaufele
Jun 23, 1999·Current Opinion in Genetics & Development·J S Seeler, A Dejean

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.