Nuclear-encoded cytochrome c oxidase subunit 4 regulates BMI1 expression and determines proliferative capacity of high-grade gliomas

Oncotarget
Claudia R OlivaCorinne E Griguer

Abstract

Nuclear-encoded cytochrome c oxidase subunit 4 (COX4) is a key regulatory subunit of mammalian cytochrome c oxidase, and recent studies have demonstrated that COX4 isoform 1 (COX4-1) could have a role in glioma chemoresistance. The Polycomb complex protein BMI1 is a stem cell regulatory gene implicated in the pathogenesis of many aggressive cancers, including glioma. This study sought to determine if COX4 regulates BMI1 and modulates tumor cell proliferation. Using The Cancer Genome Atlas database and a retrospective data set from patients with glioblastoma multiforme, we found that BMI1 expression levels positively correlated with COX4-1 expression and overall survival. Whereas COX4-1 promoted cell growth by increasing BMI1 expression, COX4-2 inhibited cell growth even in cells overexpressing BMI1. We also demonstrate that COX4-1 attenuates mitochondrial reactive oxygen species (ROS) production, which is required for COX4-1-mediated effects on BMI1 expression and cell proliferation. Notably, mice bearing COX4-1-expressing glioma cell xenografts quickly developed invasive tumors characterized by the presence of multiple lesions positive for Ki-67, BMI1, and COX4-1, whereas mice bearing COX4-2-expressing xenografts rarely develo...Continue Reading

References

May 30, 1997·Biochimica Et Biophysica Acta·L I Grossman, M I Lomax
Aug 15, 1997·European Journal of Biochemistry·S ArnoldB Kadenbach
Oct 18, 2000·Free Radical Biology & Medicine·B KadenbachE Bender
Jul 31, 2002·The Lancet Oncology·Shi-Ming TuChristopher J Logothetis
Feb 24, 1956·Science·O WARBURG
Jun 3, 2004·Cancer Research·Rebecca L ElstromCraig B Thompson
Jun 23, 2004·The Journal of Biological Chemistry·Hermann SchäggerUlrich Brandt
Aug 3, 2004·Nature Medicine·Bert Vogelstein, Kenneth W Kinzler
Aug 4, 2004·The Lancet Oncology·François BergerDidier Wion
Aug 26, 2004·The Journal of Biological Chemistry·Jian Li CampianJohn W Eaton
Jun 17, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Dusan ZencakYvan Arsenijevic
Sep 30, 2005·Journal of Neuro-oncology·Corinne E GriguerG Yancey Gillespie
Feb 17, 2007·The Journal of Biological Chemistry·Jian Li CampianJohn W Eaton
Oct 16, 2007·Cancer Cell·Sophia W M BruggemanMaarten van Lohuizen
Aug 14, 2008·Proceedings of the National Academy of Sciences of the United States of America·Jennifer Shepard DoveyJacqueline A Lees
Nov 6, 2008·PloS One·Corinne E GriguerG Yancey Gillespie
May 23, 2009·Science·Matthew G Vander HeidenCraig B Thompson
Jul 17, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Mohamed AbdouhGilbert Bernier
Dec 22, 2009·Journal of Cancer Research and Clinical Oncology·Da-wei LiZhi-hai Peng
Sep 28, 2010·The Journal of Biological Chemistry·Claudia R OlivaCorinne E Griguer
Oct 26, 2010·The Journal of Biological Chemistry·Wichit SuthammarakMargaret M Sedensky
Apr 22, 2011·Nature Reviews. Cancer·Willem H KoppenolChi V Dang
Aug 2, 2011·Biochimica Et Biophysica Acta·Denis PierronLawrence I Grossman
Sep 9, 2011·Proceedings of the National Academy of Sciences of the United States of America·Erina VlashiFrank Pajonk
Oct 27, 2011·Molecular Cancer Therapeutics·Braden C McFarlandEtty N Benveniste
Jun 26, 2012·Advances in Experimental Medicine and Biology·Denis PierronLawrence I Grossman
Aug 23, 2012·American Journal of Clinical Pathology·Tonia CenciLuigi Maria Larocca
Jan 29, 2013·Journal of Neuro-oncology·Reena P ThomasSeema Nagpal

❮ Previous
Next ❯

Citations

Jun 9, 2017·Oxidative Medicine and Cellular Longevity·Christopher A SinklerMaik Hüttemann
Nov 21, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yuehui ZhangGuochang Hu
Sep 10, 2020·Cancers·Md Yousuf AliCorinne E Griguer
Aug 4, 2016·American Journal of Physiology. Cell Physiology·Tomas A SchifferFilip J Larsen
Feb 6, 2016·Clinical Science·Malgorzata RakPierre Rustin
Feb 6, 2017·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Danielle PorplyciaChristopher D Moyes
Sep 30, 2016·The Journal of Biological Chemistry·Claudia R OlivaCorinne E Griguer
Sep 21, 2018·Cell Communication and Signaling : CCS·Claudia R OlivaCorinne E Griguer
Jan 30, 2018·Biochimica Et Biophysica Acta. Reviews on Cancer·Catherine J LibbyAnita B Hjelmeland

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
xenografts
flow cytometry

Related Concepts

Related Feeds

Cancer Stem Cells in Glioblastoma

Glioblastoma is the most common and aggressive type of brain tumor. It contains a population of tumor initiating stem cell-like cells known as cancer stem cells. Investigations are ongoing into these cancer stem cells found in these solid tumors which are highly resistance to treatment. Here is the latest research on cancer stem cells in glioblastoma.

Cancer Epigenetics and Chromatin (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. This feed focuses on chromatin and its role in cancer epigenetics please follow this feed to learn more.

Cancer Epigenetics Chromatin Complexes (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. This feed focuses on chromatin complexes and their role in cancer epigenetics.