Nuclear enlargement and DNA synthesis in mouse epidermis treated with carcinogen and promotor

Experimentelle Pathologie
A J Ingram, P Grasso


An autoradiographic investigation was made into the causes of nuclear size increase observed in the mouse epidermis within a few days of topical benzpyrene treatment. The effects of croton oil pretreatment of posttreatment in combination with benzpyrene were examined to see what effect a growth stimulus had on this response. The degree of nuclear size increase induced in the epidermis suggested that some ploidy level increase resulted from combined croton oil and benzpyrene treatment and evidence was found of a G2 block occurring in association with this. Enhancement of nuclear size increase by croton oil highlighted the importance of a growth stimulus in carcinogen induced nuclear enlargement and the implications of this are discussed. Disappearance of enlarged nuclei was seen when mice were kept for 5 days after combined croton oil and benzpyrene treatment in spite of a reduced cell loss compared with croton oil treatment alone.


May 1, 1973·Cell and Tissue Kinetics·W Oehlert
Aug 1, 1971·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M Gronow


Jun 1, 1990·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R S AhmedR H Hinton
Oct 1, 1994·Toxicology in Vitro : an International Journal Published in Association with BIBRA·C WestmorelandP Grasso

Related Concepts

Cell Cycle
Cell Nucleus
Neoplastic Cell Transformation
Croton Oil
DNA, Double-Stranded
M Phase, Mitotic

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