PMID: 26324128Sep 2, 2015Paper

Nuclear Export as a Novel Therapeutic Target: The CRM1 Connection

Current Cancer Drug Targets
Chuanwen LuWeimin Gao

Abstract

The integrity of eukaryotic cellular function depends on molecular and biochemical compartmentalization. The transport of macromolecules between compartments requires specific and energydriven mechanisms. It occurs through a class of transport proteins known as karyopherins, which are divided in three different groups (exportins, importins, and transportins). The ubiquitous exportin Chromosome Region Maintenance 1 (CRM1) is involved in the transport of many proteins and RNA molecules from nucleus to cytoplasm. We have reviewed the available evidence supporting the relevance of CRM1 in the biology of several human neoplasms, its potential role in drug resistance, and its promise as a therapeutic target. Here we discuss different cancer related proteins (tumor suppressor genes, oncogenes, and enzymatic therapeutic targets), their function, and their association with CRM1, as well as agents that specifically inhibit CRM1, their mechanism of action, and their clinical relevance in certain human neoplasms. The directionality of nuclear transport and the specific molecular cargo in question are of paramount importance when examining the effects that CRM1 inhibition may have on cellular pathophysiology. The available data point out th...Continue Reading

Citations

Jul 14, 2017·Frontiers in Microbiology·Cynthia Mathew, Reena Ghildyal
May 19, 2019·Cancer Chemotherapy and Pharmacology·David M EvansBeverly A Teicher
Oct 18, 2019·Bioscience, Biotechnology, and Biochemistry·Hepan ZhuHaoran Qian
Dec 20, 2018·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Dongqing YanMichael W Deininger
May 22, 2021·Brain : a Journal of Neurology·Terouz PashaFrank Hirth

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