Nuclear FABP7 immunoreactivity is preferentially expressed in infiltrative glioma and is associated with poor prognosis in EGFR-overexpressing glioblastoma.

BMC Cancer
Yu LiangNalin Gupta

Abstract

We previously identified brain type fatty acid-binding protein (FABP7) as a prognostic marker for patients with glioblastoma (GBM). Increased expression of FABP7 is associated with reduced survival. To investigate possible molecular mechanisms underlying this association, we compared the expression and subcellular localization of FABP7 in non-tumor brain tissues with different types of glioma, and examined the expression of FABP7 and epidermal growth factor receptor (EGFR) in GBM tumors. Expression of FABP7 in non-tumor brain and glioma specimens was examined using immunohistochemistry, and its correlation to the clinical behavior of the tumors was analyzed. We also analyzed the association between FABP7 and EGFR expression in different sets of GBM specimens using published DNA microarray datasets and semi-quantitative immunohistochemistry. In vitro migration was examined using SF763 glioma cell line. FABP7 was present in a unique population of glia in normal human brain, and its expression was increased in a subset of reactive astrocytes. FABP7 immunoreactivity in grade I pilocytic astrocytoma was predominantly cytoplasmic, whereas nuclear FABP7 was detected in other types of infiltrative glioma. Nuclear, not cytoplasmic, FABP...Continue Reading

References

Feb 1, 1994·Proceedings of the National Academy of Sciences of the United States of America·S H Khan, S Sorof
Oct 4, 1996·The Journal of Biological Chemistry·X XuS Muallem
Oct 4, 1996·The Journal of Biological Chemistry·L Z XuN Heintz
Dec 31, 1997·Biochimica Et Biophysica Acta·F ShimizuT Fujiwara
Sep 1, 1999·Proceedings of the National Academy of Sciences of the United States of America·Y ShoshanS M Staugaitis
Nov 24, 1999·Journal of Neuropathology and Experimental Neurology·A NishiyamaB D Trapp
Feb 24, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·UNKNOWN Medical Research Council Brain Tumor Working Party
Jan 10, 2003·Nucleic Acids Research·Maximilian DiehnAsh A Alizadeh
Mar 4, 2003·Molecular and Cellular Biology·Shyra J MillerNancy Ratner
Jan 22, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Tracy T BatchelorDavid N Louis
Mar 5, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Amy B HeimbergerKenneth Aldape
Apr 14, 2005·Proceedings of the National Academy of Sciences of the United States of America·Yu LiangMark A Israel
Apr 19, 2005·Journal of Neurology·Michael T WunderlichMaurice M A L Pelsers
Jun 7, 2005·International Journal of Radiation Oncology, Biology, Physics·Aimee L QuanJohn H Suh
Nov 6, 2010·Journal of the National Cancer Institute·Andrea Z LaCroixUNKNOWN PEARL Investigators

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Citations

May 9, 2012·Breast Cancer Research and Treatment·Alaa T AlshareedaAndrew R Green
Sep 22, 2009·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Jens SchittenhelmRudi Beschorner
Sep 22, 2006·Current Opinion in Oncology·Marc SansonAlexandra Benouaich-Amiel
Jul 1, 2011·BMC Medical Genomics·Lewis J FreyMary E Edgerton
Nov 26, 2013·Molecular Neurobiology·Eli T SayeghAndrew T Parsa
Dec 1, 2007·Expert Opinion on Medical Diagnostics·Fatima W Khwaja
Nov 28, 2013·Pathology International·Yusuke MorihiroMichiyasu Suzuki
Jul 25, 2013·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Jie JiangJiping Qi
Oct 17, 2009·Brain Pathology·Craig HorbinskiIan F Pollack
Jul 11, 2013·The Journal of Biological Chemistry·Miranda BrunRoseline Godbout
Mar 22, 2014·Clinical Medicine Insights. Oncology·Cheng TanSeiichiro Ozono
Mar 11, 2018·BMC Cancer·Charlotte Aaberg-JessenBjarne W Kristensen
Jan 29, 2011·Brain Tumor Pathology·Atsushi NatsumeToshihiko Wakabayashi
Dec 12, 2012·Current Oncology Reports·Emma B Holliday, Erik P Sulman
Jul 3, 2019·The Journal of Biological Chemistry·The Minh VoRoseline Godbout
Jun 9, 2020·Cellular and Molecular Life Sciences : CMLS·Christian E BadrLoic P Deleyrolle
Feb 9, 2008·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Cristóbal Belda-IniestaRosario Perona
Apr 7, 2007·Journal of Neuro-oncology·Gentian KaloshiMarc Sanson
Oct 20, 2017·International Journal of Oncology·Xiao HanChunlin Xia
Sep 28, 2007·Neoplasia : an International Journal for Oncology Research·Raja MitaRoseline Godbout
May 16, 2012·Biochemical and Biophysical Research Communications·Rong-Zong LiuRoseline Godbout
Sep 16, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Ran MaFulai Wang
Jun 7, 2019·Cellular Signalling·Iain H McKillopKyle J Thompson

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Methods Mentioned

BETA
Protein Assay
nuclear translocation

Software Mentioned

Openlab
SPSS

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