Nuclear factor κ-light chain-enhancer of activated B cells is activated by radiotherapy and is prognostic for overall survival in patients with rectal cancer treated with preoperative fluorouracil-based chemoradiotheraphy.

International Journal of Radiation Oncology, Biology, Physics
Bert H O'NeilJoel E Tepper

Abstract

Rectal cancer is often clinically resistant to radiotherapy (RT) and identifying molecular markers to define the biologic basis for this phenomenon would be valuable. The nuclear factor κ-light chain-enhancer of activated B cells (NF-κB) is a potential anti-apoptotic transcription factor that has been associated with resistance to RT in model systems. The present study was designed to evaluate NF-κB activation in patients with rectal cancer undergoing chemoradiotherapy to determine whether NF-κB activity correlates with the outcome in rectal cancer patients. A total of 22 patients underwent biopsy at multiple points in a prospective study and the data from another 50 were analyzed retrospectively. The pretreatment tumor tissue was analyzed for multiple NF-κB subunits by immunohistochemistry. Serial tumor biopsy cores were analyzed for NF-κB-regulated gene expression using reverse transcriptase polymerase chain reaction and for NF-κB subunit nuclear localization using immunohistochemistry. Several NF-κB target genes (Bcl-2, cellular inhibitor of apoptosis protein [cIAP]2, interleukin-8, and tumor necrosis factor receptor-associated-1) were significantly upregulated by a single fraction of RT at 24 h, demonstrating for the first ...Continue Reading

References

Dec 6, 2002·Oncogene·Woong-Yang ParkJeong-Sun Seo
Aug 14, 2003·Genome Research·Kuang-Yu Jen, Vivian G Cheung
Oct 22, 2004·The New England Journal of Medicine·Rolf SauerUNKNOWN German Rectal Cancer Study Group

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Citations

Apr 24, 2010·Oncology·Soham D PuvvadaBert H O'Neil
May 28, 2020·International Journal of Molecular Sciences·Antja-Voy HartleyTao Lu
Oct 4, 2012·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Birgitte Mayland HavelundAnders Jakobsen
Mar 1, 2012·Expert Review of Molecular Diagnostics·Yu-Chang LiuJeng-Jong Hwang
Jul 25, 2021·International Journal of Molecular Sciences·Matthew MartinTao Lu
Mar 20, 2018·Translational Research : the Journal of Laboratory and Clinical Medicine·Meera PatelJoanne Edwards

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