Nuclear factor-κB activation predicts an unfavourable outcome in human upper urinary tract urothelial carcinoma

BJU International
Hsin-Chih YehWen-Jeng Wu

Abstract

to examine the hypothesis that nuclear factor-κB (NF-κB), a transcription factor involved in anti-apoptosis, invasion, and angiogenesis, plays a role in the carcinogenesis of upper urinary tract urothelial carcinoma (UUT-UC) and has prognostic value for survival. in all, 90 patients with UUT-UC [mean (range) age, 64.5 (24-84) years] who underwent surgery at our institution from January 1991 to December 2005 were included. Clinicopathological data were collected retrospectively. We performed immunohistochemical staining for NF-κB (p65) on paraffin-embedded sections of the tumour and corresponding normal tissues. The association between survival and potential prognostic factors was examined. the median follow-up was 40 months. In all, 55 patients (61.1%) with UUT-UC overexpressed cytoplasmic NF-κB, and nuclear immunoreactivity for NF-κB was detected in 24 patients (26.7%). On univariate analysis, significant prognostic factors for survival were tumour location, stage, grade, lymph node involvement, and nuclear NF-κB expression. On multivariate analysis, nuclear NF-κB positivity was an independent predictor for disease-specific survival [Cox regression hazard ratio (HR) 2.87; P= 0.025] and overall survival (HR 2.24; P= 0.037). the...Continue Reading

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Citations

Jan 14, 2016·Current Urology Reports·Qiang LiJonathan A Coleman
Feb 23, 2013·Urologic Oncology·Nilay PatelJohn Kelly
Oct 12, 2016·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Jian YangJian Guan
Jan 1, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Szu-Han ChenHung-Lung Ke
Apr 21, 2018·Biomedicines·Federica ColomboAlessandra Agresti
Nov 15, 2017·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Ricardo L FavarettoGustavo C Guimarães

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