Nuclear factor (erythroid-derived 2)-like 2 regulates drug resistance in pancreatic cancer cells.

Pancreas
Young Bin HongInsoo Bae

Abstract

To investigate the molecular basis of drug resistance in pancreatic cancer. The expression of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) levels in pancreatic cancer tissues and cell lines was analyzed. Clinical relevance between Nrf2 activation and drug resistance was demonstrated by measuring cell viability after Nrf2 and adenosine 5'-triphosphate-binding cassette, subfamily G member 2 (ABCG2) regulation by overexpression or knock-down of these genes. Activity of ABCG2 was measured by Hoechst 33342 staining. Abnormally elevated Nrf2 protein levels were observed in pancreatic cancer tissues and cell lines relative to normal pancreatic tissues. Increasing Nrf2 protein levels either by overexpression of exogenous Nrf2 or by activating endogenous Nrf2 resulted in increased drug resistance. Conversely, a reduction in endogenous Nrf2 protein levels or inactivation of endogenous Nrf2 resulted in decreased drug resistance. These changes in drug resistance or sensitivity were also positively correlated to the expression levels of Nrf2 downstream genes. Similarly, the expression of ABCG2 was correlated with drug resistance. Because the intrinsic drug resistance of pancreatic cancers is, in part, due to abnormally elevated Nrf2 p...Continue Reading

References

Dec 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·J Y ChanY W Kan
Dec 23, 1998·Proceedings of the National Academy of Sciences of the United States of America·L A DoyleD D Ross
Jun 29, 2000·The Medical Clinics of North America·A B LowenfelsD C Whitcomb
Oct 18, 2000·Proceedings of the National Academy of Sciences of the United States of America·H C HuangC B Pickett
Nov 14, 2000·The American Journal of Pathology·H OuyangM S Tsao
Dec 1, 2000·Biochemical and Biophysical Research Communications·L M Zipper, R T Mulcahy
Jul 4, 2001·Genome Research·M DeanR Allikmets
May 22, 2002·Surgical Oncology·Buckminster Farrow, B Mark Evers
Oct 3, 2002·Annual Review of Pharmacology and Toxicology·Truyen NguyenCecil B Pickett
May 25, 2004·The Journal of Biological Chemistry·Eva C VaqueroAnna S Gukovskaya
Jul 13, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·David C Whitcomb
Nov 3, 2004·Cancer Research·Insoo BaeEliot M Rosen
Jan 22, 2005·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun
Nov 19, 2005·Biochemical and Biophysical Research Communications·Hiromi OkawaMasayuki Yamamoto
Feb 2, 2006·Stem Cells·Grant A Challen, Melissa H Little
Mar 2, 2006·Molecular Cell·Balasundaram PadmanabhanMasayuki Yamamoto
Mar 7, 2006·Nature Reviews. Drug Discovery·Gergely SzakácsMichael M Gottesman
Sep 14, 2006·Annual Review of Pharmacology and Toxicology·Thomas W KenslerShyam Biswal
Oct 6, 2006·PLoS Medicine·Anju SinghShyam Biswal
Oct 19, 2006·Experimental Cell Research·Annamaria HadnagyDanuta Balicki
Jan 16, 2007·Internal Medicine·Makoto Otsuki, Mitsuo Tashiro
Jul 13, 2007·Proceedings of the National Academy of Sciences of the United States of America·Sven RottenbergPiet Borst
Aug 3, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jonathan M MaherCurtis D Klaassen
Nov 17, 2007·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Hak-Ryul KimRaekil Park
Oct 8, 2008·Antioxidants & Redox Signaling·Po Sing Leung, Yuk Cheung Chan
Dec 30, 2008·Biochimica Et Biophysica Acta·S YuberoI De Dios
Feb 3, 2009·The Journal of Biological Chemistry·Truyen NguyenCecil B Pickett
Jan 22, 2013·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal

❮ Previous
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Citations

Mar 4, 2011·Archives of Toxicology·Stephen L Slocum, Thomas W Kensler
Jan 6, 2011·Proceedings of the National Academy of Sciences of the United States of America·Dongmei RenDonna D Zhang
Dec 25, 2013·International Journal of Oncology·Hong-Quan DuongInsoo Bae
Dec 5, 2013·Endocrine-related Cancer·Yoshiaki OnoderaTakashi Suzuki
Jul 18, 2014·Virchows Archiv : an International Journal of Pathology·Makoto SanoNorimichi Nemoto
Jan 18, 2012·Biochemical Pharmacology·Karthika NatarajanDouglas D Ross
Aug 12, 2014·Biochemical Society Transactions·David J MacEwanLyubov Zaitseva
May 31, 2014·The International Journal of Biochemistry & Cell Biology·Lin Li, Po Sing Leung
Jun 29, 2015·The International Journal of Biochemistry & Cell Biology·Alastair J HayesRichard M Charnley
Sep 14, 2016·Journal of Photochemistry and Photobiology. B, Biology·Laura J BroughtonLeigh A Madden
Nov 15, 2016·Expert Review of Anticancer Therapy·Nisha Durand, Peter Storz
Jan 1, 2010·Cancers·Wolfgang HagmannRalf Jesnowski
Aug 22, 2017·Antioxidants·Justin G WilkesJoseph J Cullen
Jan 18, 2020·Future Medicinal Chemistry·Hongzhi LinHaopeng Sun
Sep 13, 2019·Cell Communication and Signaling : CCS·Jiang-Jiang QinWei-Dong Zhang
Aug 16, 2017·Acta Biochimica Et Biophysica Sinica·Wenjuan QinYufeng Jiang
Jul 8, 2020·International Journal of Molecular Sciences·Eui Joo KimJae Hee Cho
Nov 24, 2012·Oncotarget·Barak RotblatRichard A Knight
Mar 14, 2020·Pharmaceutical Research·N Basaran Mutlu-AgardanVladimir P Torchilin
Dec 11, 2014·The Journal of Biological Chemistry·Melissa L FishelMircea Ivan
Nov 14, 2019·Cancers·Alina-Andreea ZimtaIoana Berindan-Neagoe
May 20, 2017·Frontiers in Oncology·Keiko Taguchi, Masayuki Yamamoto
Oct 24, 2020·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Lingling XuDianlei Wang
Jan 28, 2021·International Journal of Molecular Sciences·Annalisa Ferino, Luigi E Xodo

❮ Previous
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