Nuclear factor kappa B: a marker of chemotherapy for human stage IV gastric carcinoma.

World Journal of Gastroenterology : WJG
You-Ming LongWen-Rui Xie

Abstract

To detect the nuclear factor kappa B (NF-kappaB) condition in human stage IV gastric carcinoma patients and to explore the correlation between NF-kappaB activation and survival of these patients after chemotherapy. Expression of NF-kappaB-p65 was determined by immunohistochemical analysis. Activity of NF-kappaB DNA-binding in carcinoma tissue was detected by electrophoretic mobility shift assay. Kaplan-Meier survival analysis was performed to show the relation between NF-kappaB and progression-free survival (PFS) or overall survival (OS) of the patients. The positive expression rate of NF-kappaB-p65 in 60 gastric cancer tissue samples was 76.7% (46/60). The expression of NF-kappaB-p65 was reduced in adjacent carcinoma and normal tissue samples. Electrophoretic mobility shift assay (EMSA) analysis showed a strong activation of NF-kappaB in cancer tissue samples. A survival difference was found in NF-kappaB-p65 positive and negative patients. NF-kappaB-p65 expression was negative in cancer tissue samples (n=14). PFS was 191.40+/-59.88 d and 152.93+/-16.99 d, respectively, in patients with positive NF-kappaB-p65 expression (n=46) (P=0.4028). The survival time of patients with negative and positive NF-kappaB-p65 expression was 425....Continue Reading

References

Jan 1, 1994·Annual Review of Cell Biology·U SiebenlistK Brown
Jan 1, 1996·Annual Review of Immunology·A S Baldwin
Aug 4, 2001·The American Journal of Pathology·F ChenX Shi
Jan 13, 2004·World Journal of Gastroenterology : WJG·Wei WangBao-Ping Yu
Apr 9, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Byung Lan LeeSeon Young Nam
Feb 20, 2007·Current Medicinal Chemistry·Marco A CalzadoM Lienhard Schmitz

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Citations

Nov 16, 2013·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Kanjoormana A ManuGautam Sethi
Dec 24, 2010·International Journal of Oral and Maxillofacial Surgery·Y NariaiJ Sekine
Feb 15, 2011·Science China. Life Sciences·Chen YaoZheng Guo
Mar 17, 2010·International Journal of Radiation Oncology, Biology, Physics·Amit K GargThomas A Buchholz
Oct 5, 2015·Asian Pacific Journal of Tropical Medicine·Xiu-Li GuoYou-Qing Xu
Mar 30, 2017·Toxins·Olga Sokolova, Michael Naumann
May 1, 2020·International Journal of Molecular Sciences·Manuela LabbozzettaPaola Poma
Mar 26, 2015·World Journal of Gastroenterology : WJG·Sahil GambhirArpita Vyas
Jun 2, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Chen YuYu Sun
Nov 2, 2019·Gene·Atena SoleimaniSeyed Mahdi Hassanian
Aug 28, 2021·Biomedicines·Supattra ChaithongyotMichael Naumann

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