Nuclear Factor-kappa B as a Resistance Factor to Platinum-Based Antineoplasic Drugs.

Metal-based Drugs
Vilma Maldonado Lagunas, Jorge Meléndez-Zajgla

Abstract

Platinum drugs continue to be major chemotherapy drugs for cancer treatment. Nevertheless, acquired or intrinsic resistance to these compounds is common in human tumors. One important mechanism for this resistance is the avoidance of cells entering the apoptotic pathway. Nuclear factor-kappa B (NF-kappa B, NF-kappaB) is a pleiotropic transcription factor key in determining the death threshold of human cells. This factor is important in the final response of cells to platinum drugs, as exemplified by in vitro and in vivo models showing that inhibition of NF-kappaB sensitizes cancer cells to the effects of these drugs. New approaches focusing on the inhibition of NF-kappaB could help to minimize or even eliminate intrinsic or acquired resistance to platinum drugs.

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Citations

Aug 29, 2020·Journal of Experimental & Clinical Cancer Research : CR·Boshi WangYizhen Liu
Oct 15, 2021·Oncogene·Dongqing HuangAmanda G Paulovich

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BETA
nuclear translocation
ubiquitination

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