Nuclear factor-kappaB activity and arterial response to balloon injury

Atherosclerosis
Bojan CercekJ Regnstrom

Abstract

We studied the effect of arterial balloon injury on nuclear factor-kappaB (NF-kappaB) mobilization and ICAM-1 expression in untreated rats and rats treated with aspirin. Baseline NF-kappaB nuclear binding in smooth muscle cells (SMC) increased two-fold within 6 h after balloon injury. The binding returned to baseline 3 days after injury. Consistently nuclear staining of p65 active subunit increased in the medial SMC following balloon injury. There was no baseline ICAM-1 expression. Within 3 days after balloon injury there was marked medial ICAM-1 expression, that localized to neointima 7 days after injury and to regrowing endothelial cells 14 days after injury. Treatment with aspirin inhibited NF-kappaB nuclear translocation and binding and was associated with reduction of ICAM-1 expression, SMC proliferation and neointimal thickening following balloon injury. These data suggest that transient mobilization of NF-kappaB in vascular SMC after balloon injury mediates ICAM-1 expression and is involved in arterial response to balloon injury.

References

May 1, 1992·The Journal of Experimental Medicine·R SchreckP A Baeuerle
Mar 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·E N HatadaC Scheidereit
Jun 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M P DuyaoG E Sonenshein
Jun 15, 1984·The American Journal of Cardiology·D P FaxonT J Ryan
Oct 1, 1995·Arteriosclerosis, Thrombosis, and Vascular Biology·W PalinskiJ L Witztum
Jan 1, 1995·Biological Chemistry Hoppe-Seyler·C KaltschmidtP A Baeuerle
Jun 1, 1993·Journal of Cardiovascular Pharmacology·J BernhardtT J Resink
Aug 1, 1993·The Journal of Clinical Investigation·P Libby, H Li
Feb 1, 1995·Circulation Research·E R EdelmanR D Rosenberg
Aug 12, 1994·Science·E Kopp, S Ghosh
Mar 1, 1993·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·T CouffinhalJ Bonnet
Oct 1, 1993·Mechanisms of Development·C KaltschmidtP A Baeuerle
Aug 10, 2000·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·J KriegsmanG Stein

❮ Previous
Next ❯

Citations

Dec 31, 2002·Journal of Molecular and Cellular Cardiology·Peter ZahradkaShawn Thomas
Nov 15, 2002·Journal of Biomedical Science·Shiow-Lin PanChe-Ming Teng
Mar 15, 2006·Cardiovascular Drugs and Therapy·Arno RuusaleppGuro Valen
Jun 1, 2005·Atherosclerosis·Mayte PozoJesús González-Cabrero
Mar 8, 2000·Atherosclerosis·B E RolfeJ H Campbell
May 25, 2002·British Journal of Pharmacology·Pasquale MaffiaArmando Ialenti
Apr 9, 2008·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jing HuangRajamma Mathew
May 19, 2010·Biomarkers in Medicine·Bernhard R WinkelmannMartin Unverdorben
Oct 17, 2008·Coronary Artery Disease·Byung-Ryul ChoDae-Joong Kim
Nov 13, 1998·Current Opinion in Lipidology·B L Thurberg, T Collins
Sep 12, 2000·Current Cardiology Reports·R C Smith, K Walsh
Nov 22, 2005·British Journal of Pharmacology·Barbara RinaldiAmelia Filippelli
Oct 11, 2005·The American Journal of Cardiology·Shigemasa TaniUNKNOWN Surugadai Atherosclerosis Regression Investigators
Feb 14, 2015·Acta Physiologica·D A ChistiakovY V Bobryshev
Feb 24, 2010·Clinical Science·Kim Van der HeidenPaul C Evans
Dec 29, 2006·Journal of Atherosclerosis and Thrombosis·Tsuyoshi ChibaKentaro Shimokado
Aug 28, 2012·The Journal of Surgical Research·Maria M StollenwerkRoland Andersson
Feb 17, 2017·Thrombosis and Haemostasis·Britta Walker-AllgaierOliver Borst
Jun 19, 2004·International Journal of Cardiovascular Interventions·Ariel FinkelsteinRaj Makkar

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.