Nuclear factor-kappaB: the enemy within

Cancer Cell
Bharat B Aggarwal

Abstract

Numerous lines of investigation suggest that nuclear factor NF-kappaB, a proinflammatory transcription factor, could promote tumorigenesis. Various inflammatory agents, carcinogens, tumor promoters, and the tumor microenvironment activate NF-kappaB. NF-kappaB proteins themselves and proteins regulated by it have been linked to cellular transformation, proliferation, apoptosis suppression, invasion, angiogenesis, and metastasis. Constitutively activated NF-kappaB is common in wide variety of tumors. Furthermore, there exists genetic evidence that NF-kappaB mediates tumorigenesis. Thus, suppression of NF-kappaB activation should be effective in the prevention and treatment of cancer.

References

Apr 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·L OsbornG J Nabel
Oct 21, 1996·International Journal of Cancer. Journal International Du Cancer·R B MyersW E Grizzle
Oct 6, 1997·The Journal of Biological Chemistry·D ChilovK Alitalo
Apr 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·C S SeitzP A Khavari
Apr 17, 1998·Cancer Metastasis Reviews·L L Thomsen, D W Miles
Jul 19, 2000·Proceedings of the National Academy of Sciences of the United States of America·D K BiswasA B Pardee
Mar 7, 2001·Lancet·F Balkwill, A Mantovani
Jun 13, 2001·Methods in Enzymology·M W MayoA S Baldwin
Sep 6, 2002·Biochemical Pharmacology·Alok C Bharti, Bharat B Aggarwal
Sep 7, 2002·International Journal of Cancer. Journal International Du Cancer·Judith H HarmeyZhongyun Dong
Apr 12, 2003·The Journal of Biological Chemistry·Gregory HelbigHarikrishna Nakshatri
Jul 19, 2003·Genes & Development·Casey J FoxCraig B Thompson
Sep 2, 2003·Nature Reviews. Immunology·Bharat B Aggarwal
Feb 3, 2004·Oncogene·Thomas D GilmoreDaniel T Starczynowski
Aug 3, 2004·Nature Reviews. Immunology·Jukka Vakkila, Michael T Lotze

❮ Previous
Next ❯

Citations

Jun 1, 2011·Archivum Immunologiae Et Therapiae Experimentalis·Jacek WilczynskiMalgorzata Czyz
Aug 27, 2010·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·M JennyDietmar Fuchs
Jul 12, 2011·Cellular and Molecular Life Sciences : CMLS·Pearl P Y LieDolores D Mruk
Jul 4, 2007·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Zhao-Hui Wu, Shigeki Miyamoto
Oct 10, 2009·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Shephali Bhatnagar, Ashok Kumar
Mar 31, 2007·Cancer Chemotherapy and Pharmacology·Karen W Barbour, Franklin G Berger
Apr 12, 2011·Cancer Chemotherapy and Pharmacology·Shuang-Jia WangXue-Wei Bai
May 13, 2008·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Yi-Yen LeeTai-Tong Wong
Oct 1, 2008·International Journal of Colorectal Disease·Noyko StanilovSpaska Stanilova
Jan 27, 2007·Archives of Dermatological Research·Davina A Lewis, Dan F Spandau
Aug 28, 2009·Molecules and Cells·Chul-Yong ParkSoon B Hwang
Feb 13, 2009·Apoptosis : an International Journal on Programmed Cell Death·Han-Ming Shen, Vinay Tergaonkar
Apr 27, 2011·Apoptosis : an International Journal on Programmed Cell Death·Ji-Hyun KimSung-Hoon Kim
Apr 16, 2013·Clinical & Experimental Metastasis·Sheeja AravindanNatarajan Aravindan
Nov 12, 2005·Molecular and Cellular Biochemistry·Yadong ZhangFei Chen
Oct 6, 2006·Molecular and Cellular Biochemistry·Johnny BarrGovindarajan T Ramesh
Jul 16, 2008·Pharmaceutical Research·Preetha AnandBharat B Aggarwal
Aug 31, 2013·Applied Biochemistry and Biotechnology·Babajan BanaganapalliSuresh Kumar Chitta
Oct 28, 2008·Biological Trace Element Research·Inas A AsfourOmar M Fathey
Apr 26, 2011·Genes & Nutrition·Simone ReuterBharat B Aggarwal
May 17, 2013·Journal of Physiology and Biochemistry·Wu XuStephan W Morris
Jun 19, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Guang-Li WuFu-Li Wang
Jun 1, 2005·Brain, Behavior, and Immunity·Valentin A Pavlov, Kevin J Tracey
Apr 2, 2013·Journal of Ethnopharmacology·Niramai FangkrathokBungorn Sripanidkulchai
May 17, 2005·Neuroscience Letters·Carmen NoelkerRichard Dodel
May 10, 2005·Experimental Cell Research·Hideyasu MiuraShoji Yamaoka
Jul 17, 2010·Expert Reviews in Molecular Medicine·Marc E SeamanKimberly A Kelly
Feb 11, 2012·Journal of Agricultural and Food Chemistry·Monica WhentDevanand Luthria

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Cancer Genomics (Keystone)

Cancer genomics approaches employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest research using such technologies in this feed.

B-Cell Leukemia (Keystone)

B-cell leukemia includes various types of lymphoid leukemia that affect B cells. Here is the latest research on B-cell leukemia.

Angiogenesis Inhibitors to Treat Cancer

Cancer treatments including angiogenesis inhibitors prevent tumor cells from receiving nutrients and oxygen. Here is the latest research on angiogenesis inhibitors for the treatment of cancer.

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Breast Tumorigenesis

Breast tumorigenesis involves the production or formation of tumor(s) in breast tissue. Discover the latest research on breast tumorigenesis here.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.

BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Related Papers

Biochemical Pharmacology
Shishir Shishodia, Bharat B Aggarwal
Nature
Lisa M Coussens, Zena Werb
© 2021 Meta ULC. All rights reserved