Nuclear Functions of TOR: Impact on Transcription and the Epigenome.

Genes
R Nicholas Laribee, Ronit Weisman

Abstract

The target of rapamycin (TOR) protein kinase is at the core of growth factor- and nutrient-dependent signaling pathways that are well-known for their regulation of metabolism, growth, and proliferation. However, TOR is also involved in the regulation of gene expression, genomic and epigenomic stability. TOR affects nuclear functions indirectly through its activity in the cytoplasm, but also directly through active nuclear TOR pools. The mechanisms by which TOR regulates its nuclear functions are less well-understood compared with its cytoplasmic activities. TOR is an important pharmacological target for several diseases, including cancer, metabolic and neurological disorders. Thus, studies of the nuclear functions of TOR are important for our understanding of basic biological processes, as well as for clinical implications.

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Citations

Sep 10, 2020·Genes·Ivana Bjedov, Charalampos Rallis
Nov 6, 2020·Current Opinion in Lipidology·Evelyn Orsó, Ralph Burkhardt
Mar 17, 2021·Nature Cell Biology·Ronit Weisman
Jul 13, 2021·Frontiers in Molecular Biosciences·Araceli González-JiménezOlga Calvo

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Methods Mentioned

BETA
immunoprecipitation
fluorescence resonance energy transfer
ubiquitination
acetylation
histone acetylation
environmental stress
ChIP
GTPase

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