Nuclear history of a pre-mRNA determines the translational activity of cytoplasmic mRNA

The EMBO Journal
K MatsumotoA P Wolffe

Abstract

The pathways of synthesis and maturation of pre-messenger RNA in the nucleus have a direct effect on the translational efficiency of mRNA in the cytoplasm. The transcription of intron-less mRNA in vivo directs this mRNA towards translational silencing. The presence of an intron at the 5' end of the transcript relieves this silencing, whereas an intron at the 3' end further represses translation. These regulatory events are strongly dependent on the transcription of pre-mRNA in the nucleus. The impact of nuclear history on regulatory events in the cytoplasm provides a novel mechanism for the control of gene expression.

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Mar 10, 2011·Molecular Biotechnology·Natasa SkokoEmanuele Buratti
Mar 20, 2002·Molecular and Cellular Endocrinology·R G Gosden
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