Nuclear hypochromasia: Shedding light on the "lightness" of high-grade urothelial carcinoma.

Diagnostic Cytopathology
Evan S Stern, Momin T Siddiqui

Abstract

The Paris system (TPS) has provided a standardized classification for reporting urinary cytology, specifically high-grade urothelial carcinoma (HGUC). While hyperchromasia is well described in HGUC, there exists little data on nuclear hypochromasia in HGUC. Our focus was to investigate the incidence of hypochromasia in HGUC and if it should become a criterion for HGUC. All cases of HGUC at our institution for a 3-year interval (2017-2019) using TPS were reviewed. Each case had a single ThinPrep slide and concurrent biopsy or resection specimen to confirm the diagnosis within 30 days. The presence of hypochromasia was evaluated, and cases with hypochromasia were stratified based on the tumor cell percentage. Cases with hypochromasia in 5% or greater of the tumor cells were considered "positively identified" for hypochromasia. We reviewed 117 cases of HGUC and identified nuclear hypochromasia in 12 cases (10.2%) within 5% or greater of the tumor cells. These 12 cases were further assessed based on if tumor cells showed hypochromasia in 5%-49% of the sample, or greater than 50% of the sample. Hypochromasia in 5%-49% of tumor cells was present in 8/117 cases (6.8%); whereas in 50% or greater samples 4/117 cases (3.4%) showed hypoch...Continue Reading

References

Apr 16, 2013·Journal of the National Comprehensive Cancer Network : JNCCN·Peter E ClarkUNKNOWN National Comprehensive Cancer Network (NCCN)
Jun 20, 2016·Acta Cytologica·Güliz A BarkanDorothy L Rosenthal
Aug 31, 2018·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Francesco PiercontiAntonio Lopez-Beltran
Jan 1, 2018·Journal of the American Society of Cytopathology : JASC·Juan XingLiron Pantanowitz
Nov 3, 2020·Journal of the American Society of Cytopathology : JASC·Andrew A Renshaw, Edwin W Gould

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Citations

Dec 7, 2021·Diagnostic Cytopathology·Derek B AllisonChristopher J VandenBussche

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