Nuclear interactions in proton therapy: dose and relative biological effect distributions originating from primary and secondary particles
The dose distribution delivered in charged particle therapy is due to both primary and secondary particles. The secondaries, originating from non-elastic nuclear interactions, are of interest for three reasons. First, if fast Monte Carlo treatment planning is envisaged, the question arises whether all nuclear interaction products deliver a significant contribution to the total dose and, hence, need to be tracked. Second, there could be an enhanced relative biological effectiveness (RBE) due to low energy and/or heavy secondaries. Third, neutrons originating from nuclear interactions may deliver dose outside the target volume. The particle yield from different nuclear interaction channels as a function of proton penetration depth was studied theoretically for different proton beam energies. Three-dimensional dose distributions from primary and secondary particles were simulated for an unmodulated 160 MeV proton beam with and without including a slice of bone material and for a spread-out Bragg peak (SOBP) of 3 x 3 x 3 cm3 in water. Secondary protons deliver up to 10% of the total dose proximal to the Bragg peak of an unmodulated proton beam and they affect the flatness of the SOBP. Furthermore, they cause a dose build-up due to ...Continue Reading
The relative biological effectiveness of 160 MeV protons--II. Biological data and their interpretation in terms of microdosimetry
The relative biological effectiveness of 60Co gamma-rays, 55 kVp X-rays, 250 kVp X-rays, and 11 MeV electrons at low doses
The irradiation of V79 mammalian cells by protons with energies below 2 MeV. Part I: Experimental arrangement and measurements of cell survival
Computer simulations of nuclear reactions induced by incident protons in the energy range of 100 to 500 MeV in a human body
Inactivation and mutation induction in V79 cells by low energy protons: re-evaluation of the results at the LNL facility
The relative cellular radiosensitivity of 30 human in vitro cell lines of different histological type to high LET 62.5 MeV (p-->Be+) fast neutrons and 4 MeV photons
Effects of track structure and cell inactivation on the calculation of heavy ion mutation rates in mammalian cells
Calculation of relative biological effectiveness for proton beams using biological weighting functions
Monte Carlo and analytical calculation of proton pencil beams for computerized treatment plan optimization
Extension of a numerical algorithm to proton dose calculations. I. Comparisons with Monte Carlo simulations
Microdosimetry spectra of the Loma Linda proton beam and relative biological effectiveness comparisons
Calculation of the spatial variation of relative biological effectiveness in a therapeutic proton field for eye treatment
Radiobiological significance of beamline dependent proton energy distributions in a spread-out Bragg peak
The general relation between tissue response to x-radiation (alpha/beta-values) and the relative biological effectiveness (RBE) of protons: prediction by the Katz track-structure model
Comparative risk assessment of secondary cancer incidence after treatment of Hodgkin's disease with photon and proton radiation
Inactivation of aerobic and hypoxic cells from three different cell lines by accelerated (3)He-, (12)C- and (20)Ne-ion beams
A fast numerical method for calculating the 3D proton dose profile in a single-ring wobbling spreading system
Monte Carlo calculations for absolute dosimetry to determine machine outputs for proton therapy fields
Monte Carlo study of the potential reduction in out-of-field dose using a patient-specific aperture in pencil beam scanning proton therapy
Evaluation of inelastic hadronic processes for 250 MeV proton interactions in tissue and iron using GEANT4
Verification of absolute ionization chamber dosimetry in a proton beam using carbon activation measurements
Accurate Monte Carlo simulations for nozzle design, commissioning and quality assurance for a proton radiation therapy facility
The role of nonelastic reactions in absorbed dose distributions from therapeutic proton beams in different medium
Geometrical splitting technique to improve the computational efficiency in Monte Carlo calculations for proton therapy
Comparison of secondary neutron dose in proton therapy resulting from the use of a tungsten alloy MLC or a brass collimator system
Water and tissue equivalence of a new PRESAGE(®) formulation for 3D proton beam dosimetry: a Monte Carlo study
Interpretation of proton relative biological effectiveness using lesion induction, lesion repair, and cellular dose distribution
An analytical model of leakage neutron equivalent dose for passively-scattered proton radiotherapy and validation with measurements
Induction of in situ DNA double-strand breaks and apoptosis by 200 MeV protons and 10 MV X-rays in human tumour cell lines
Results of a multicentric in silico clinical trial (ROCOCO): comparing radiotherapy with photons and protons for non-small cell lung cancer
Technical Note: Radiation properties of tissue- and water-equivalent materials formulated using the stoichiometric analysis method in charged particle therapy
Analysis of the physical interactions of therapeutic proton beams in water with the use of Geant4 Monte Carlo calculations
Fast multipurpose Monte Carlo simulation for proton therapy using multi- and many-core CPU architectures
Potential outcomes of modalities and techniques in radiotherapy for patients with hypopharyngeal carcinoma
Experimental and Monte Carlo studies of fluence corrections for graphite calorimetry in low- and high-energy clinical proton beams
Dual ring multilayer ionization chamber and theory-based correction technique for scanning proton therapy
Factors influencing the performance of patient specific quality assurance for pencil beam scanning IMPT fields
Present developments in reaching an international consensus for a model-based approach to particle beam therapy
A phenomenological relative biological effectiveness approach for proton therapy based on an improved description of the mixed radiation field
Energy Spectra of Protons and Generated Secondary Electrons around the Bragg Peak in Materials of Interest in Proton Therapy
The influence of nuclear interactions on ionization chamber perturbation factors in proton beams: FLUKA simulations supported by a Fano test
Assigning nonelastic nuclear interaction cross sections to Hounsfield units for Monte Carlo treatment planning of proton beams
Neutron production from beam-modifying devices in a modern double scattering proton therapy beam delivery system
Test of the nuclear interaction model in SHIELD-HIT and comparison to energy distributions from GEANT4
Simulation of organ-specific patient effective dose due to secondary neutrons in proton radiation treatment
A filtering approach based on Gaussian-powerlaw convolutions for local PET verification of proton radiotherapy
Calculation of the positron distribution from 15O nuclei formed in nuclear reactions in human tissue during proton therapy
A novel methodology to assess linear energy transfer and relative biological effectiveness in proton therapy using pairs of differently doped thermoluminescent detectors
Characterization of a multilayer ionization chamber prototype for fast verification of relative depth ionization curves and spread-out-Bragg-peaks in light ion beam therapy
Dose build-up effects induced by delta electrons and target fragments in proton Bragg curves-measurements and simulations
Secondary neutron doses received by paediatric patients during intracranial proton therapy treatments
A Monte Carlo based radiation response modelling framework to assess variability of clinical RBE in proton therapy
Monte Carlo study of out-of-field exposure in carbon-ion radiotherapy: Organ doses in pediatric brain tumor treatment
A dose calculation algorithm with correction for proton-nucleus interactions in non-water materials for proton radiotherapy treatment planning
Monte Carlo calculation of beam quality correction factors in proton beams using detailed simulation of ionization chambers
Modeling the radiation-induced cell death in a therapeutic proton beam using thermoluminescent detectors and radiation transport simulations
Contribution to dose in healthy tissue from secondary target fragments in therapeutic proton, He and C beams measured with CR-39 plastic nuclear track detectors
Fluence correction factors for graphite calorimetry in a low-energy clinical proton beam: I. Analytical and Monte Carlo simulations
MEASUREMENT OF NEUTRON AMBIENT DOSE EQUIVALENT IN PROTON RADIOTHERAPY WITH LINE-SCANNING AND WOBBLING MODE TREATMENT SYSTEM
Analytical linear energy transfer model including secondary particles: calculations along the central axis of the proton pencil beam
Monte Carlo implementation of new algorithms for the evaluation of averaged-dose and -track linear energy transfers in 62 MeV clinical proton beams.
Biological Effects of Scattered Versus Scanned Proton Beams on Normal Tissues in Total Body Irradiated Mice: Survival, Genotoxicity, Oxidative Stress and Inflammation
Report on G4-Med, a Geant4 benchmarking system for medical physics applications developed by the Geant4 Medical Simulation Benchmarking Group
Microdosimetry of a therapeutic proton beam with a mini-TEPC and a MicroPlus-Bridge detector for RBE assessment
Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.
Synthetic Genetic Array Analysis
Synthetic genetic arrays allow the systematic examination of genetic interactions. Here is the latest research focusing on synthetic genetic arrays and their analyses.
Congenital hyperinsulinism is caused by genetic mutations resulting in excess insulin secretion from beta cells of the pancreas. Here is the latest research.
Neural Activity: Imaging
Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.
Chronic Fatigue Syndrome
Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.
Epigenetic memory refers to the heritable genetic changes that are not explained by the DNA sequence. Find the latest research on epigenetic memory here.
Cell Atlas of the Human Eye
Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.
Femoral Neoplasms are bone tumors that arise in the femur. Discover the latest research on femoral neoplasms here.
STING Receptor Agonists
Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.