Nuclear localization of COX-2 in relation to the expression of stemness markers in urinary bladder cancer.

Mediators of Inflammation
Raynoo ThananShosuke Kawanishi

Abstract

Inflammation may activate stem cells via prostaglandin E2 (PGE2) production mediated by cyclooxygenase-2 (COX-2) expression. We performed an immunohistochemical analysis of the expression of stemness markers (Oct3/4 and CD44v6) and COX-2 in urinary bladder tissues obtained from cystitis and cancer patients with and without Schistosoma haematobium infections. Immunoreactivity to Oct3/4 was significantly higher in S. haematobium-associated cystitis and cancer tissues than in normal tissues. CD44v6 expression was significantly higher in bladder cancer without S. haematobium than in normal tissues. COX-2 was located in the cytoplasmic membrane, cytoplasm, and nucleus of the cancer cells. Interestingly, the nuclear localization of COX-2, which was reported to function as a transcription factor, was significantly associated with the upregulation of Oct3/4 and CD44v6 in bladder cancer tissues with and without S. haematobium infection, respectively. COX-2 activation may be involved in inflammation-mediated stem cell proliferation/differentiation in urinary bladder carcinogenesis.

References

Sep 1, 1995·Environmental Health Perspectives·J Raloff
Sep 1, 1996·The British Journal of Ophthalmology·P Ursell
Jun 3, 1999·Oncogene·N HornigoldM A Knowles
Feb 24, 2001·Nature·C Picallo
Mar 10, 2001·The American Journal of Pathology·A RistimäkiC Haglund
Jun 13, 2001·American Journal of Physiology. Cell Physiology·H ParfenovaC W Leffler
Nov 2, 2001·Nature·T ReyaI L Weissman
Aug 1, 2002·Japanese Journal of Cancer Research : Gann·Shiho OhnishiShosuke Kawanishi
Sep 11, 2002·Trends in Cell Biology·Tom BurdonPierre Savatier
Dec 20, 2002·Nature·Lisa M Coussens, Zena Werb
Jan 4, 2003·Nature Reviews. Molecular Cell Biology·Helmut PontaPeter A Herrlich
Jun 5, 2004·Biochemical and Biophysical Research Communications·Ning MaShosuke Kawanishi
Apr 15, 2005·Nature·Tannishtha Reya, Hans Clevers
Jul 12, 2005·European Urology·Daya Shankar Lal SrivastavaRama Devi Mittal
Aug 8, 2006·Progress in Neurobiology·Huimin WangJoe Z Tsien
Jan 6, 2007·International Journal of Cancer. Journal International Du Cancer·Yaser AtlasiAhmad-Reza Bahrami
May 8, 2007·Urologic Oncology·Dominique S Michaud
Jun 5, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Marta Sanchez-CarbayoCarlos Cordon-Cardo
Jun 8, 2007·Nature·Keisuke OkitaShinya Yamanaka
Oct 24, 2007·Cancer Biology & Therapy·Caitlin Marie LoganMarco Cassone
Nov 22, 2007·Science·Junying YuJames A Thomson
Apr 2, 2008·Laboratory Investigation; a Journal of Technical Methods and Pathology·Michail Shipitsin, Kornelia Polyak
Jul 26, 2008·Journal of Cellular Biochemistry·Norman J Maitland, Anne T Collins
Oct 15, 2009·Parasite Immunology·B J Vennervald, K Polman
Mar 23, 2010·Cell·Sergei I GrivennikovMichael Karin
Apr 21, 2010·The Journal of Urology·Tobias KlatteAllan J Pantuck
Nov 12, 2010·Breast Cancer Research and Treatment·Paola MaroniMaria Alfonsina Desiderio

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Citations

Sep 26, 2013·The American Journal of Dermatopathology·Asmaa G AbdouHala F Abd-Elsattar Saif
Jan 6, 2016·International Journal of Molecular Sciences·Tomokazu OhishiToshiro Migita
Dec 31, 2014·International Journal of Molecular Sciences·Raynoo ThananMariko Murata
Jul 15, 2015·Cancer Epidemiology·Nut KoonrungsesomboonEvaristus Chibunna Mbanefo
Jan 3, 2014·Oxidative Medicine and Cellular Longevity·Shiho OhnishiShosuke Kawanishi
Apr 14, 2016·Mediators of Inflammation·Raynoo ThananShosuke Kawanishi
Sep 21, 2016·Mediators of Inflammation·Shumin WangMariko Murata
Aug 11, 2016·BMC Complementary and Alternative Medicine·Lavanya ReddivariJairam K P Vanamala
Jul 12, 2017·International Journal of Urology : Official Journal of the Japanese Urological Association·Dong Fang, Hiroshi Kitamura
Mar 7, 2018·Journal of Biomedical Science·Ain Zubaidah Ayob, Thamil Selvee Ramasamy
Aug 13, 2015·Virchows Archiv : an International Journal of Pathology·Gabriella NesiRaffaella Santi
Dec 5, 2019·Journal of Cellular and Molecular Medicine·Chunhua LinJitao Wu
Oct 21, 2018·Environmental Health and Preventive Medicine·Mariko Murata
Jan 5, 2017·Genes and Environment : the Official Journal of the Japanese Environmental Mutagen Society·Shosuke KawanishiMariko Murata
Oct 5, 2018·Hormones & Cancer·Waleeporn KaewlertRaynoo Thanan
Sep 22, 2020·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Denise BelgoroskyAna María Eiján
Mar 27, 2018·Journal of Cellular Physiology·Denise BelgoroskyBetiana Lerner
Sep 27, 2018·Cancers·Walaa Hamed Shaker NasryChelsea K Martin
Jan 14, 2020·Prostaglandins & Other Lipid Mediators·Benjamin L WoolbrightJohn A Taylor
Nov 26, 2020·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·Dengbao LiFangmin Chen

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Methods Mentioned

BETA
biopsy
fluorescence microscopy

Software Mentioned

SPSS19

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