Nuclear localization of heme oxygenase-1 is associated with tumor progression of head and neck squamous cell carcinomas

Experimental and Molecular Pathology
Norberto A GandiniAlejandro C Curino

Abstract

The expression of heme oxygenase-1 (HO-1) was shown to be increased in multiple tumors compared with their surrounding healthy tissues and was also observed to be up-regulated in oral squamous cell carcinomas (OSCC). However, conflicting results were obtained and little information is available regarding HO-1 significance in head and neck squamous cell carcinoma (HNSCC). Therefore, the aim of the present study was to perform a wide screening of HO-1 expression in a large collection of human primary HNSCCs and to correlate the results with clinical and pathological parameters. For this purpose, we investigated the expression of this protein by immunohistochemistry (IHC) in tissue microarrays (TMAs) of HNSCC and in an independent cohort of paraffin-embedded tumor specimens. HO-1 expression was further validated by real-time qPCR performed on selected laser capture-microdissected (LCM) oral tissue samples. Both the number of HO-1-positive samples and HO-1 immunoreactivity in the cancerous tissues were significantly higher than those in the non-tumor tissues. These results were confirmed at the mRNA level. Interestingly, HO-1 localization was observed in the nucleus, and the rate of nuclear HO-1 in HNSCC was higher than that in non...Continue Reading

References

Oct 1, 1968·Proceedings of the National Academy of Sciences of the United States of America·R TenhunenR Schmid
Jul 5, 1996·Biochemical and Biophysical Research Communications·E HaraS Shibahara
Jan 1, 1997·Proceedings of the Society for Experimental Biology and Medicine·A I GoodmanN G Abraham
Aug 28, 2001·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·S H Snyder, D E Barañano
Jan 12, 2002·The Journal of Biological Chemistry·Rio HoriMakoto Suematsu
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Mar 12, 2005·CA: a Cancer Journal for Clinicians·D Max ParkinPaola Pisani
May 18, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Pascal O BerberatHelmut Friess
Sep 27, 2005·Biochemical and Biophysical Research Communications·Mahin D Maines, Peter E M Gibbs
Sep 6, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Alfredo A MolinoloJ Silvio Gutkind
Sep 8, 2007·Antioxidants & Redox Signaling·Alicja JozkowiczJozef Dulak
Feb 15, 2008·International Journal of Oral and Maxillofacial Surgery·J LeeE-C Kim
Feb 22, 2008·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun
May 22, 2008·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Shiuan-Shinn LeeYu-Chao Chang
Jan 26, 2010·Experimental and Molecular Pathology·María E FermentoMaría M Facchinetti
Jul 8, 2010·Cells, Tissues, Organs·María M FacchinettiAlejandro C Curino
Aug 14, 2010·Current Drug Targets·Halina WasAlicja Jozkowicz
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg

❮ Previous
Next ❯

Citations

Nov 5, 2013·Antioxidants & Redox Signaling·Phyllis A Dennery
Nov 5, 2013·Antioxidants & Redox Signaling·Barbara WegielLeo E Otterbein
Nov 5, 2013·Antioxidants & Redox Signaling·Louise L DunnRoland Stocker
Nov 16, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Norberto A GandiniAlejandro C Curino
Jan 3, 2014·Antioxidants & Redox Signaling·Phyllis A Dennery
Sep 23, 2014·Experimental and Molecular Pathology·Nancy Carolina AndrésMaría Marta Facchinetti
Sep 23, 2014·Experimental and Molecular Pathology·María E FermentoAlejandro C Curino
Nov 10, 2013·Free Radical Biology & Medicine·Hye-Kyung Na, Young-Joon Surh
Apr 18, 2015·Journal of Biomedical Science·Lee-Young Chau
Nov 29, 2016·Nutrition and Cancer·Eliana Noelia AlonsoAlejandro Carlos Curino
May 6, 2017·Antioxidants·Mariapaola NittiAnna Lisa Furfaro
Jul 7, 2017·American Journal of Physiology. Renal Physiology·Ravindra BodduLisa M Curtis
Nov 20, 2019·Oncogene·Prashant V BommiSrilata Bagchi
Sep 15, 2016·Oncotarget·Luca VanellaGiovanni Li Volti
Mar 5, 2017·Antioxidants & Redox Signaling·Giovanni Li VoltiIgnazio Barbagallo
Mar 4, 2014·Journal of Neuro-oncology·Débora G SalomónMaría M Facchinetti
Nov 30, 2018·Antioxidants & Redox Signaling·Norberto Ariel GandiniMaría Marta Facchinetti
Nov 20, 2016·Apoptosis : an International Journal on Programmed Cell Death·Siyuan WangWenping Lin
Mar 1, 2019·International Journal of Molecular Sciences·Daiana B LeonardiJavier Cotignola
Feb 23, 2020·Frontiers in Immunology·Giacomo CanesinBarbara Wegiel
Oct 15, 2013·Cancer Research·Barbara WegielLeo E Otterbein
Apr 20, 2021·Frontiers in Immunology·Kim Ngan Luu HoangJames N Arnold
Jun 3, 2021·Antioxidants·Mariapaola NittiAnna Lisa Furfaro
Jun 4, 2021·European Journal of Pharmacology·Jingmin ChePeng Shang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.

Angiogenesis Inhibitors to Treat Cancer

Cancer treatments including angiogenesis inhibitors prevent tumor cells from receiving nutrients and oxygen. Here is the latest research on angiogenesis inhibitors for the treatment of cancer.