Nuclear localization of Tob is important for regulation of its antiproliferative activity

Oncogene
J Kawamura-TsuzukuT Yamamoto

Abstract

TOB: is a member of an antiproliferative gene family that includes btg1, pc3/tis21/btg2, pc3b, ana/btg3, and tob2. Exogenous overexpression of the family proteins suppresses cell proliferation. These proteins participate in transcriptional regulation of several genes. Here, we show that Tob is a nuclear protein that is imported into the nucleus through a nuclear localization signal (NLS)-mediated mechanism. Mutation in the NLS sequence of Tob affects its nuclear localization and impairs antiproliferative activity. Additionally, Tob contains a nuclear export signal (NES). In oncogenic ErbB2-transformed cells, nuclear export of Tob is facilitated by NES-mediated mechanism, resulting in decrease of its antiproliferative activity. These results indicate that regulation of nuclear localization of Tob is important for its antiproliferative activity.

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Citations

Apr 17, 2008·Immunologic Research·Jaime F ModianoDonald Bellgrau
Mar 12, 2009·The Journal of Biological Chemistry·Masataka HoriuchiFuyuhiko Inagaki
Jun 2, 2010·The Journal of Experimental Medicine·Karen J HoSeth J Karp
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Aug 17, 2011·International Journal of Molecular Sciences·Jing YuanKui Li
Oct 3, 2013·International Journal of Molecular Sciences·Yang ZhaoHua-Chuan Zheng
Dec 24, 2015·International Journal of Molecular Sciences·Hun Seok LeeYoung Kee Shin
Jul 29, 2008·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Hironobu YanagieMasazumi Eriguchi
Jan 29, 2005·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Kentaro OkochiTadashi Yamamoto
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Feb 17, 2007·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Shunji Jia, Anming Meng
Apr 2, 2008·Cancer Science·Takashi MiyasakaTadashi Yamamoto
Sep 12, 2009·Journal of Cellular Physiology·G Sebastiaan Winkler
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Nov 19, 2014·International Journal of Oncology·Mitsuro KandaYasuhiro Kodera

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