Nuclear maturity and oocyte morphology after stimulation with highly purified follicle stimulating hormone compared to human menopausal gonadotrophin

Human Reproduction
B ImthurnP J Keller

Abstract

Several studies have shown that high concentrations of luteinizing hormone (LH) in the follicular phase of stimulation can have a negative effect on oocyte quality, pregnancy rate and incidence of miscarriage. The aim of the present study was to examine the effects of highly purified follicle stimulating/hormone (FSH HP) on ovarian stimulation and particularly on nuclear maturity and morphological appearance of the oocyte in intracytoplasmic sperm injection (ICSI) therapy and to compare the results with human menopausal gonadotrophin (HMG) stimulation. For this purpose, 50 patients for ICSI (HMG: 30; FSH HP: 20) and 26 patients for in-vitro fertilization (IVF; HMG: 14, FSH HP: 12) were stimulated with either HMG or FSH HP using a short-term protocol. Patients were divided into the two groups according to the first letter of their family name. No differences were observed among the groups in relation to patient age, duration of stimulation, number of aspirated oocytes or maturity of the oocyte-cumulus complex. After removal of the cumulus-corona cells in the ICSI oocytes, a significantly higher proportion of oocytes in the FSH HP group were nuclear mature (metaphase II) than in the HMG group (FSH HP: 88.8%, HMG: 80.6%; P = 0.009...Continue Reading

Citations

Jun 1, 2005·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Batool Hossein RashidiNavid Khanafshar
Sep 7, 2002·Fertility and Sterility·UNKNOWN European and Israeli Study Group on Highly Purified Menotropin versus Recombinant Follicle-Stimulating Hormone
Nov 5, 2002·Fertility and Sterility·Andres SalumetsTimo Tuuri
Aug 2, 2003·Trends in Endocrinology and Metabolism : TEM·Marco FilicoriSilvia Bernardi
Mar 24, 2004·Journal of Assisted Reproduction and Genetics·Yi-Chi LinFu-Jen Huang
Jan 29, 2013·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Francisco FábreguesJuan Balasch
Aug 16, 2011·Reproductive Biomedicine Online·Péter FancsovitsJános Urbancsek
Mar 17, 2011·Fertility and Sterility·Krinos M TrokoudesXiao Zhang
Jun 23, 2006·Reproductive Biomedicine Online·Basak Balaban, Bulent Urman
Apr 14, 2009·Fertility and Sterility·Wei ShaQing-Yuan Sun
Sep 8, 2007·Gynécologie, obstétrique & fertilité·P Clément
May 8, 2007·Fertility and Sterility·Byung Chul JeeUNKNOWN Seoul National University College of Medicine Assisted Reproductive Technology (SMART) Study Group
Nov 26, 2013·Molecular Reproduction and Development·Sarah L FieldNicolas M Orsi
Jun 15, 2012·Acta Biologica Hungarica·P FancsovitsJ Urbancsek
Oct 18, 2008·Reproductive Toxicology·Alexandre FeugierMarie Claraz
Sep 14, 2007·Cephalalgia : an International Journal of Headache·C GaulP S Sándor

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