May 24, 2020

Nuclear mechanotransduction in stem cells

Current Opinion in Cell Biology
Mehdi S HamoudaKevin J Chalut

Abstract

In development and in homeostatic maintenance of tissues, stem cells and progenitor cells are constantly subjected to forces. These forces can lead to significant changes in gene expression and function of stem cells, mediating self-renewal, lineage specification, and even loss of function. One of the ways that has been proposed to mediate these functional changes in stem cells is nuclear mechanotransduction - the process by which forces are converted to signals in the nucleus. The purpose of this review is to discuss the means by which mechanical signals are transduced into the nucleus, through the linker of nucleoskeleton and cytoskeleton (LINC) complex and other nuclear envelope transmembrane (NET) proteins, which connect the cytoskeleton to the nucleus. We discuss how LINC/NETs confers tissue-specific mechanosensitivity to cells and further elucidate how LINC/NETs acts as a control center for nuclear mechanical signals, regulating both gene expression and chromatin organization. Throughout, we primarily focus on stem cell-specific examples, notwithstanding that this is a nascent field. We conclude by highlighting open questions and pointing the way to enhanced research efforts to understand the role nuclear mechanotransduct...Continue Reading

  • References
  • Citations

References

  • We're still populating references for this paper, please check back later.
  • References
  • Citations

Citations

  • This paper may not have been cited yet.

Mentioned in this Paper

Chromatin Organization
Stem Cells
Gene Expression
SUN-KASH Complex
Cytoskeleton
Nuclear Matrix
Stem Cell Self-Renewal
Mechanotransduction, Cellular
Mosquito Nets
LEMD2 gene

Related Feeds

Cambridge Stem Cell Institute - Researcher Network

Cambridge Stem Cell Institute's mission is to transform human health through a deep understanding of stem cell biology. Follow this feed to stay up to date on research published in this group.

Related Papers

Current Opinion in Cell Biology
Cátia S JanotaEdgar R Gomes
Annual Review of Biomedical Engineering
Rui P MartinsDavid A Lee
© 2020 Meta ULC. All rights reserved