Nuclear Membrane Rupture and Its Consequences.

Annual Review of Cell and Developmental Biology
John Maciejowski, Emily M Hatch

Abstract

The nuclear envelope is often depicted as a static barrier that regulates access between the nucleus and the cytosol. However, recent research has identified many conditions in cultured cells and in vivo in which nuclear membrane ruptures cause the loss of nuclear compartmentalization. These conditions include some that are commonly associated with human disease, such as migration of cancer cells through small spaces and expression of nuclear lamin disease mutations in both cultured cells and tissues undergoing nuclear migration. Nuclear membrane ruptures are rapidly repaired in the nucleus but persist in nuclear compartments that form around missegregated chromosomes called micronuclei. This review summarizes what is known about the mechanisms of nuclear membrane rupture and repair in both the main nucleus and micronuclei, and highlights recent work connecting the loss of nuclear integrity to genome instability and innate immune signaling. These connections link nuclear membrane rupture to complex chromosome alterations, tumorigenesis, and laminopathy etiologies.

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Citations

Feb 10, 2021·Nature Cell Biology·Adam Karoutas, Asifa Akhtar
Jan 22, 2021·Molecular Cell·Lisa MohrJohn Maciejowski
Mar 5, 2021·Current Opinion in Cell Biology·Nishit SrivastavaMatthieu Piel
Mar 7, 2021·Cells·Arianna CalistriCristina Parolin
Apr 12, 2021·Seminars in Cell & Developmental Biology·Anna E Mammel, Emily M Hatch
Jun 5, 2021·Frontiers in Immunology·Roberto AmadioFederica Benvenuti
Jun 17, 2021·PLoS Genetics·Jose Verdezoto MosqueraJames R Priess
Jul 4, 2021·Trends in Biochemical Sciences·Marilena Wischnewski, Andrea Ablasser
Aug 31, 2021·Current Opinion in Cell Biology·Guilherme Pedreira de Freitas NaderMatthieu Piel
Sep 14, 2021·The Journal of Cell Biology·Leslie A SepaniacJason Stumpff
Oct 13, 2021·Circulation·Miguel Sáinz-JaspeadoLena Claesson-Welsh

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