Nuclear organization in human sperm: preliminary evidence for altered sex chromosome centromere position in infertile males.

Human Reproduction
Katie A FinchD K Griffin

Abstract

Many genetic defects with a chromosomal basis affect male reproduction via a range of different mechanisms. Chromosome position is a well-known marker of nuclear organization, and alterations in standard patterns can lead to disease phenotypes such as cancer, laminopathies and epilepsy. It has been demonstrated that normal mammalian sperm adopt a pattern with the centromeres aligning towards the nuclear centre. The purpose of this study was to test the hypothesis that altered chromosome position in the sperm head is associated with male infertility. The average nuclear positions of fluorescence in-situ hybridization signals for three centromeric probes (for chromosomes X, Y and 18) were compared in normoozoospermic men and in men with compromised semen parameters. In controls, the centromeres of chromosomes X, Y and 18 all occupied a central nuclear location. In infertile men the sex chromosomes appeared more likely to be distributed in a pattern not distinguishable from a random model. Our findings cast doubt on the reliability of centromeric probes for aneuploidy screening. The analysis of chromosome position in sperm heads should be further investigated for the screening of infertile men.

Citations

Aug 13, 2008·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Marta OlszewskaMaciej Kurpisz
Sep 29, 2011·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Dimitris IoannouDarren Karl Griffin
Jun 30, 2012·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·D IoannouD K Griffin
Nov 13, 2012·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·N M MillanH G Tempest
Feb 8, 2011·Asian Journal of Andrology·Michael C HannHelen G Tempest
May 21, 2010·Cold Spring Harbor Perspectives in Biology·Carmelo FerraiAna Pombo
Sep 1, 2011·Molecular and Cellular Probes·D IoannouD K Griffin
Dec 19, 2015·Journal of Assisted Reproduction and Genetics·Dimitrios IoannouHelen G Tempest
May 2, 2013·Systems Biology in Reproductive Medicine·Sofia Alçada-MoraisJoão Ramalho-Santos
Mar 1, 2013·Systems Biology in Reproductive Medicine·Naazish AlladinClifford L Librach
Aug 26, 2016·Scientific Reports·Ewa WilandMaciej Kurpisz
Feb 2, 2011·Cytogenetic and Genome Research·C TempladoA Estop
Jan 8, 2011·Cytogenetic and Genome Research·K G L Fonseka, D K Griffin
Nov 20, 2010·Cytogenetic and Genome Research·D Ioannou, D K Griffin
Jan 3, 2018·Systems Biology in Reproductive Medicine·Dimitrios Ioannou, Helen G Tempest
Jan 1, 2010·Nano Reviews·Dimitris Ioannou, Darren K Griffin
Feb 13, 2017·Chromosoma·Josefa CabreroJuan Pedro M Camacho
Mar 21, 2018·AIMS Genetics·Vadim ChaginOlga Mudrak
Sep 20, 2018·Journal of Assisted Reproduction and Genetics·Zaida SarrateJoan Blanco
Jul 25, 2021·International Journal of Molecular Sciences·Kara J TurnerDarren K Griffin
May 22, 2009·Current Opinion in Obstetrics & Gynecology

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