Nuclear organization of cholinergic, putative catecholaminergic, serotonergic and orexinergic systems in the brain of the African pygmy mouse (Mus minutoides): organizational complexity is preserved in small brains

Journal of Chemical Neuroanatomy
Jean-Leigh KrugerPaul R Manger

Abstract

This study investigated the nuclear organization of four immunohistochemically identifiable neural systems (cholinergic, catecholaminergic, serotonergic and orexinergic) within the brain of the African pygmy mouse (Mus minutoides). The African pygmy mice studied had a brain mass of around 275 mg, making these the smallest rodent brains to date in which these neural systems have been investigated. In contrast to the assumption that in this small brain there would be fewer subdivisions of these neural systems, we found that all nuclei generally observed for these systems in other rodent brains were also present in the brain of the African pygmy mouse. As with other rodents previously studied in the subfamily Murinae, we observed the presence of cortical cholinergic neurons and a compactly organized locus coeruleus. These two features of these systems have not been observed in the non-Murinae rodents studied to date. Thus, the African pygmy mouse displays what might be considered a typical Murinae brain organization, and despite its small size, the brain does not appear to be any less complexly organized than other rodent brains, even those that are over 100 times larger such as the Cape porcupine brain. The results are consistent...Continue Reading

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Citations

Jan 27, 2015·Frontiers in Neural Circuits·Marie-Eve Laramée, Denis Boire
Aug 5, 2016·The Journal of Comparative Neurology·Laura J MahadyElliott J Mufson
May 12, 2019·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·S M Matt, P J Gaskill
Sep 13, 2019·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Illke B MalungoPaul R Manger
Oct 5, 2021·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Victoria M WilliamsPaul R Manger

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