Nuclear Overhauser Enhancement imaging of glioblastoma at 7 Tesla: region specific correlation with apparent diffusion coefficient and histology

PloS One
Daniel PaechAlexander Radbruch

Abstract

To explore the correlation between Nuclear Overhauser Enhancement (NOE)-mediated signals and tumor cellularity in glioblastoma utilizing the apparent diffusion coefficient (ADC) and cell density from histologic specimens. NOE is one type of chemical exchange saturation transfer (CEST) that originates from mobile macromolecules such as proteins and might be associated with tumor cellularity via altered protein synthesis in proliferating cells. For 15 patients with newly diagnosed glioblastoma, NOE-mediated CEST-contrast was acquired at 7 Tesla (asymmetric magnetization transfer ratio (MTRasym) at 3.3ppm, B1 = 0.7 μT). Contrast enhanced T1 (CE-T1), T2 and diffusion-weighted MRI (DWI) were acquired at 3 Tesla and coregistered. The T2 edema and the CE-T1 tumor were segmented. ADC and MTRasym values within both regions of interest were correlated voxelwise yielding the correlation coefficient rSpearman (rSp). In three patients who underwent stereotactic biopsy, cell density of 12 specimens per patient was correlated with corresponding MTRasym and ADC values of the biopsy site. Eight of 15 patients showed a weak or moderate positive correlation of MTRasym and ADC within the T2 edema (0.16≤rSp≤0.53, p<0.05). Seven correlations were st...Continue Reading

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Citations

Feb 5, 2016·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Moritz ZaissAlexander Radbruch
Jul 28, 2016·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Vitaliy KhlebnikovOlivier Mougin
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Oct 1, 2016·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Kimberly L DesmondGreg J Stanisz
Aug 23, 2018·Journal of Magnetic Resonance Imaging : JMRI·Constantin DreherDaniel Paech
Nov 16, 2018·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Anagha DeshmaneKlaus Scheffler
Oct 20, 2018·NMR in Biomedicine·Zhongliang Zu
Apr 20, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Andrzej LiebertArmin M Nagel
Jul 31, 2019·NMR in Biomedicine·Johannes BreitlingMoritz Zaiss
Jun 20, 2019·Frontiers in Oncology·Hatef MehrabianGreg J Stanisz
May 26, 2017·NMR in Biomedicine·Yuanyu ShenRenhua Wu
Sep 13, 2021·Investigative Radiology·Tanja PlattDaniel Paech

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Methods Mentioned

BETA
biopsy
Chemical Exchange
protein folding
biopsies
surgical resection

Software Mentioned

MATLAB
SigmaPlot
NIH ImageJ
syngo
SPSS Statistics
SPSS
ImageJ
iPS
MITK

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