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Nuclear pore complex composition: a new regulator of tissue-specific and developmental functions

Nature Reviews. Molecular Cell Biology

Oct 24, 2012

Marcela Raices, Maximiliano A D'Angelo

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Abstract

Nuclear pore complexes (NPCs) are multiprotein aqueous channels that penetrate the nuclear envelope connecting the nucleus and the cytoplasm. NPCs consist of multiple copies of roughly 30 different proteins known as nucleoporins (NUPs). Due to their essential role in controlling nucleoc...read more

Mentioned in this Paper

Complex (molecular entity)
Protoplasm
Cell Nucleus
Nuclear Pore Complex Proteins
Nuclear Envelope
Cell Type
Nuclear Pore Complex
Drosophila melanogaster
Cytoplasm
Nuclear Export
4
1
333
Paper Details
References
  • References149
  • Citations120
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  • References149
  • Citations120
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Nuclear Pore Complex

Nuclear pore complexes are large macromolecules composed of individual proteins called nucleoporins. These complexes perforate the nuclear envelope and allow the exchange of substances between the nucleus and the cytoplasm. Here is the latest research on nuclear pore complexes.

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Nuclear pore complex composition: a new regulator of tissue-specific and developmental functions

Nature Reviews. Molecular Cell Biology

Oct 24, 2012

Marcela Raices, Maximiliano A D'Angelo

PMID: 23090414

DOI: 10.1038/nrm3461

Abstract

Nuclear pore complexes (NPCs) are multiprotein aqueous channels that penetrate the nuclear envelope connecting the nucleus and the cytoplasm. NPCs consist of multiple copies of roughly 30 different proteins known as nucleoporins (NUPs). Due to their essential role in controlling nucleoc...read more

Mentioned in this Paper

Complex (molecular entity)
Protoplasm
Cell Nucleus
Nuclear Pore Complex Proteins
Nuclear Envelope
Cell Type
Nuclear Pore Complex
Drosophila melanogaster
Cytoplasm
Nuclear Export
4
1
333

Feeds With Similar Papers

Nuclear Envelope Dynamics

The nuclear envelope provides barrier between the nucleus and cytoplasm. It plays a key role in transport function and nuclear growth, organization, and integrity. Discover the latest research on nuclear envelope dynamics here.

Nuclear Transport

Nuclear transport refers to the import and export of large molecules into and out of the nucleus. This process is controlled by the nuclear pore complexes, where cargo bearing a nuclear localization or export signal is transported via nuclear transport receptors. Find the latest research on nuclear transport here.

Related Papers

Annual Review of Biophysics

Functional architecture of the nuclear pore complex

Annual Review of BiophysicsMay 15, 2012
Einat GrossmanMonika Zwerger
EMBO Reports

The role of nuclear pores in gene regulation, development and disease

EMBO ReportsJune 23, 2009
M Capelson, Martin W Hetzer
Paper Details
References
  • References149
  • Citations120
12345...
  • References149
  • Citations120
12345...

Download from

Publisher
PubMed
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