Nuclear protein 1 induced by ATF4 in response to various stressors acts as a positive regulator on the transcriptional activation of ATF4.

IUBMB Life
Hyeon-Ok JinIn-Chul Park

Abstract

Nuclear protein 1 (NUPR1) was originally identified as p8, a member of the family of HMG-I/Y transcription factors induced in response to various cellular stressors. However, the signaling pathway underlying NUPR1 induction by cellular stresses remains to be established. In this study, we found that the expression of NUPR1 by various stresses induced by activating transcription factor 4 (ATF4). Loss of ATF4 using siRNA significantly diminished NUPR1 expression. Overexpression of ATF4 caused NUPR1 levels to rise. NUPR1 expression was associated with enhanced transcriptional activation of genes of ATF4 downstream, suggesting that the protein promoted the transcription of stress-regulated genes via positive feedback on the ATF4 pathway.

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Citations

Aug 27, 2011·Biochemical and Biophysical Research Communications·J AverousP Fafournoux
Mar 19, 2011·Biochemical and Biophysical Research Communications·Hyeon-Ok JinIn-Chul Park
May 20, 2015·Toxicology and Applied Pharmacology·Hyeon-Ok JinJin Kyung Lee
Feb 24, 2011·Journal of Cellular Physiology·Maria Jose SandiJuan L Iovanna
Dec 5, 2014·Journal of Cancer Research and Clinical Oncology·Sung-Eun HongIn-Chul Park
Jul 28, 2016·Journal of the American Society of Nephrology : JASN·Pierre GalichonEric Rondeau
Aug 23, 2016·The Journal of Clinical Investigation·Adriano MaidaAdam J Rose
Feb 9, 2017·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Ali Burak OzkayaHikmet Hakan Aydin
Jul 26, 2019·PLoS Neglected Tropical Diseases·Priscila R AndradeRobert L Modlin
Sep 16, 2016·EMBO Reports·Karolina Pakos-ZebruckaAdrienne M Gorman
Apr 10, 2019·International Journal of Molecular Sciences·Junsei MimuraKen Itoh
Aug 16, 2019·The Journal of Biological Chemistry·Inna A NikonorovaTracy G Anthony
Mar 29, 2019·American Journal of Physiology. Gastrointestinal and Liver Physiology·Kamal AlbarazanjiPamela J Hornby
Feb 6, 2020·Proceedings of the National Academy of Sciences of the United States of America·Anthony C BrandtCarol L Williams
Jul 21, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Heike NiessnerFriedegund Meier
Jan 30, 2021·Nature Communications·Jiao LiuDaolin Tang
Jul 4, 2020·Current Cancer Drug Targets·Salma M A MansourSameh H Soror
Aug 8, 2021·Cancers·Can HuangJuan Iovanna
Aug 18, 2021·The International Journal of Biochemistry & Cell Biology·Eugenia LicariPaola Falletta

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