Nuclear receptor function requires a TFTC-type histone acetyl transferase complex

Molecular Cell
Junn YanagisawaShigeaki Kato

Abstract

Nuclear receptors (NRs) regulate transcription in a ligand-dependent way through two types of coactivator complexes: the p160/CBP histone acetyl transferase (HAT) complex and the DRIP/TRAP/SMCC complex without HAT activity. Here we identified a large human (h) coactivator complex necessary for the estrogen receptor alpha (ERalpha) transactivation. This complex contains the GCN5 HAT, the c-Myc interacting protein TRRAP/PAF400, TAF(II)30, and other subunits. Similarly to known TFTC (TBP-free TAF(II)-containing)-type HAT complexes (hTFTC, hPCAF, and hSTAGA), TRRP directly interacted with liganded ER alpha, or other NRs. ER alpha transactivation was enhanced by the purified complex in vitro. Antisense TRRAP RNA inhibited estrogen-dependent cell growth of breast cancer cells. Thus, the isolated TFTC-type HAT complex acts as a third class of coactivator complex for NR function.

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Citations

Nov 8, 2005·Cancer Chemotherapy and Pharmacology·Shigeaki KatoTakahiro Matsumoto
Mar 17, 2004·Biochimica Et Biophysica Acta·H Karimi Kinyamu, Trevor K Archer
Dec 14, 2002·Biochemical and Biophysical Research Communications·Takashi SatoShigeaki Kato
Jun 18, 2003·Biochemical and Biophysical Research Communications·Ken IshitaniShigeaki Kato
Dec 18, 2010·Nature·Wen-Wei TsaiMichelle Craig Barton
Mar 20, 2012·Genes & Development·Gianpiero SpedaleW W M Pim Pijnappel
Aug 22, 2007·Molecular and Cellular Biology·Hirochika KitagawaLeonard P Freedman
Aug 31, 2006·Molecular and Cellular Biology·Yukiyo TateishiJunn Yanagisawa
Oct 31, 2007·Molecular and Cellular Biology·Xiaohui LiuErnest Martinez
Feb 6, 2008·Molecular and Cellular Biology·Armin M Gamper, Robert G Roeder
Apr 9, 2008·Molecular and Cellular Biology·Atsushi YokoyamaShigeaki Kato
May 2, 2007·Molecular and Cellular Biology·Junko MiyamotoShigeaki Kato
Sep 16, 2003·Molecular and Cellular Biology·Nickolai A BarlevShelley L Berger
May 19, 2005·Molecular and Cellular Biology·Mattia FrontiniLàszlò Tora
Jul 31, 2004·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·John D Moore, Jocelyn E Krebs
Aug 12, 2005·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Wei Xu
Feb 18, 2011·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Chris Barnett, Jocelyn E Krebs
Jan 19, 2011·Endocrine Journal·Hirochika KitagawaShigeaki Kato
Nov 3, 2010·Proceedings of the National Academy of Sciences of the United States of America·Chihiro AkimotoShigeaki Kato
Jul 23, 2003·Proceedings of the National Academy of Sciences of the United States of America·Hirotaka KawanoShigeaki Kato
May 28, 2005·Proceedings of the National Academy of Sciences of the United States of America·Yoshikazu MasuhiroShigeaki Kato
Aug 22, 2002·Proceedings of the National Academy of Sciences of the United States of America·Sailesh SurapureddiJanardan K Reddy
Sep 9, 2008·Bioscience, Biotechnology, and Biochemistry·Takuya MurataShigeaki Kato
Apr 13, 2007·Expert Opinion on Drug Metabolism & Toxicology·Michael Murray
Jul 25, 2006·Critical Reviews in Biochemistry and Molecular Biology·Mary C Thomas, Cheng-Ming Chiang
Jan 26, 2007·Molecular and Cellular Endocrinology·Mi-Sun KimShigeaki Kato
Jan 10, 2012·Gene·Bernhard Lüscher, Jörg Vervoorts
Feb 15, 2011·Trends in Biochemical Sciences·Shigeaki KatoRyoji Fujiki
Aug 31, 2010·Biochimica Et Biophysica Acta·Sukesh R Bhaumik

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