Nuclear Receptor Function through Genomics: Lessons from the Glucocorticoid Receptor

Trends in Endocrinology and Metabolism : TEM
Daniel M Cohen, David J Steger

Abstract

Unlocking the therapeutic potential of the glucocorticoid receptor (GR) has motivated a search for small molecules that selectively modulate its ability to activate or repress gene transcription. Recently, breakthrough studies in the field of genomics have reinvigorated debate over longstanding transcriptional models explaining how GR controls tissue-specific gene expression. Here, we highlight these genomic studies with the dual goals of advancing understanding of nuclear receptor-mediated transcription and stimulating thought on the development of anti-inflammatory and immunosuppressive ligands for GR that have reduced harmful effects on metabolism.

References

Oct 6, 1998·Annual Review of Biochemistry·J L Workman, R E Kingston
Sep 14, 2001·The Journal of Biological Chemistry·A D Wallace, J A Cidlowski
Jan 18, 2003·The Journal of Allergy and Clinical Immunology·Donald Y M Leung, John W Bloom
Jul 28, 2004·Trends in Biochemical Sciences·Laszlo Nagy, John W R Schwabe
Mar 9, 2006·The Journal of Allergy and Clinical Immunology·Kazuhiro ItoIan M Adcock
Apr 7, 2007·Current Opinion in Rheumatology·John Kirwan, Lynsey Power
Feb 29, 2008·The Journal of Steroid Biochemistry and Molecular Biology·Raymond D Blind, Michael J Garabedian
May 17, 2008·Molecular Endocrinology·Weiwei ChenMichael J Garabedian
Apr 18, 2009·Science·Sebastiaan H MeijsingKeith R Yamamoto
Jun 6, 2009·Seminars in Immunopathology·Mario NotiThomas Brunner
Mar 31, 1936·The Journal of Experimental Medicine·C N Long, F D Lukens
May 19, 2010·Genes & Development·David J StegerMitchell A Lazar
Aug 20, 2010·Nature·Michael H KageyRichard A Young
Jan 25, 2011·Nature Genetics·Sam JohnJohn A Stamatoyannopoulos
Dec 21, 2011·Disease Models & Mechanisms·Yaniv ShpilbergMichael C Riddell
Dec 1, 2012·Journal of Molecular Endocrinology·Juan LiuGuoxian Ding
Dec 12, 2012·Nature Structural & Molecular Biology·William H HudsonEric A Ortlund
Jan 15, 2013·Trends in Endocrinology and Metabolism : TEM·John M Busillo, John A Cidlowski
Jan 19, 2013·Science·Cosmas D ArnoldAlexander Stark
Feb 9, 2013·Endocrine Development·Evangelia CharmandariGeorge P Chrousos
Mar 26, 2013·Nature Methods·J Christof M GebhardtX Sunney Xie
Jun 4, 2013·Nature Structural & Molecular Biology·Lisa C WatsonKeith R Yamamoto
Oct 3, 2013·The Journal of Allergy and Clinical Immunology·Robert H Oakley, John A Cidlowski
Oct 16, 2013·Proceedings of the National Academy of Sciences of the United States of America·Morgane Thomas-ChollierSebastiaan H Meijsing

❮ Previous
Next ❯

Citations

Nov 8, 2018·The Journal of Endocrinology·Dieuwertje C E SpaandermanJan Kroon
Mar 30, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Abudukadier AbuliziDaniel F Vatner
Aug 6, 2019·Scandinavian Journal of Immunology·Jacek Hawiger, Jozef Zienkiewicz
Jan 29, 2020·The Journal of Biological Chemistry·David Diaz-JimenezJohn A Cidlowski
Sep 10, 2020·Journal of the Endocrine Society·Aristotle PanayiotopoulosSteven Ghanny
Aug 2, 2017·Cellular & Molecular Immunology·Jaydeep Bhat, Dieter Kabelitz
Oct 28, 2019·Journal of Cardiovascular Pharmacology and Therapeutics·Helana JeriesTony Hayek
Mar 28, 2021·Biochemical and Biophysical Research Communications·Su-Jun LeeMasahiko Negishi
Apr 24, 2021·The Journal of Biological Chemistry·Anthony N GerberSarah K Sasse
Jun 4, 2021·Frontiers in Immunology·David Diaz-JimenezJohn A Cidlowski

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved